Role of CDK1 in Translational Regulation in the M-Phase

Jaroslav Kalous; Denisa Jansova; Andrej Susor

doi:10.20944/preprints202004.0530.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 28 April 2020 / Approved: 30 April 2020 / Online: 30 April 2020 (13:46:44 CEST)

Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival. In this review we summarize the involvement of active CDK1 in the initiation and elongation steps of protein synthesis in eukaryotes. During its activation CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. Our review provides insights into gene expression regulation during the transcriptionally silent cell cycle/M-phase and describes quantitative and qualitative translational changes based on the extramitotic role of the cell cycle master regulator CDK1, to optimize temporal synthesis of proteins to sustain division-related processes: mitosis and cytokinesis.

CDK1; eIF4F; mTOR; mRNA translation; M-phase

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Role of CDK1 in Translational Regulation in the M-Phase

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