Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Emerging Approach for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

Zahra Asadzadeh
,
Elham Safarzadeh
,
Sahar Safaei
,
Ali Baradaran
,
Ali Mohammadi
,
Khalil Haji‐Asgarzadeh
ORCID logo ,
Afshin Derakhshani
ORCID logo ,
Antonella Argentiero
,
Nicola Silvestris
* ORCID logo ,
Behzad Baradaran
* ORCID logo
Version 1 : Received: 12 March 2020 / Approved: 13 March 2020 / Online: 13 March 2020 (10:04:56 CET)

A peer-reviewed article of this Preprint also exists.

Asadzadeh, Z.; Safarzadeh, E.; Safaei, S.; Baradaran, A.; Mohammadi, A.; Hajiasgharzadeh, K.; Derakhshani, A.; Argentiero, A.; Silvestris, N.; Baradaran, B. Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death. Cancers 2020, 12, 1047. Asadzadeh, Z.; Safarzadeh, E.; Safaei, S.; Baradaran, A.; Mohammadi, A.; Hajiasgharzadeh, K.; Derakhshani, A.; Argentiero, A.; Silvestris, N.; Baradaran, B. Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death. Cancers 2020, 12, 1047.

Abstract

Cell death resistance is a key feature of tumor cells. One of the main anti-cancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.

Keywords

Immunogenic cell death; DAMPs; cell death resistance; immunotherapy; combination therapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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