Working Paper Review Version 2 This version is not peer-reviewed

Purinergic Signaling in Neutrophils During Inflammatory Diseases

Version 1 : Received: 10 March 2020 / Approved: 11 March 2020 / Online: 11 March 2020 (10:42:45 CET)
Version 2 : Received: 4 September 2021 / Approved: 8 September 2021 / Online: 8 September 2021 (13:16:11 CEST)

How to cite: Sun, H. Purinergic Signaling in Neutrophils During Inflammatory Diseases. Preprints 2020, 2020030185 Sun, H. Purinergic Signaling in Neutrophils During Inflammatory Diseases. Preprints 2020, 2020030185


Purinergic signaling is that nucleotides (especially ATP) and adenosine are utilized as transmitter molecules, which play an important role in the immune system. In the extracellular ventricle, ATP plays a significant role of pro-inflammatory molecules mainly through activating P2 receptors, while adenosine plays the role as anti-inflammatory molecule mainly through activating P1 receptors. As we know,neutrophils are the most abundant immune cells in our circulation and have become an essential part of coordinating a series of complex events during inflammatory diseases. However, due to the destruction of inflammatory substances from neutrophils, the activation of neutrophils is fine-tuned, and purinergic signaling is associated with this process. As a matter of fact, altering the balance between P2 and P1 signals is of great importance for neutrophils to exert immune activities properly. Here, we review the role of purinergic signaling in regulatory function of neutrophils during inflammatory disease, and then discuss the potential contribution of targeted purinergic signals in the treatment of the neutrophil during inflammatory diseases.


purinergic signaling; regulatory role; neutrophils; inflammation


Medicine and Pharmacology, Immunology and Allergy

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