Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults

Version 1 : Received: 21 February 2020 / Approved: 23 February 2020 / Online: 23 February 2020 (13:05:55 CET)

A peer-reviewed article of this Preprint also exists.

Kaufman, C.S.; Vidoni, E.D.; Burns, J.M.; Alwatban, M.R.; Billinger, S.A. Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults. Nutrients 2020, 12, 697. Kaufman, C.S.; Vidoni, E.D.; Burns, J.M.; Alwatban, M.R.; Billinger, S.A. Self-Reported Omega-3 Supplement Use Moderates the Association between Age and Exercising Cerebral Blood Flow Velocity in Older Adults. Nutrients 2020, 12, 697.

Journal reference: Nutrients 2020, 12, 697
DOI: 10.3390/nu12030697

Abstract

Cerebral blood flow (CBF) decreases across the lifespan, and chronic conditions such as dementia and stroke accelerate this decline. Impaired CBF results in reduced delivery of oxygen and nutrients, which can damage the brain over time. Thus, there is a need to identify lifestyle interventions including diet and exercise to maintain CBF with aging and in the presence of chronic disease. In the present study, we used transcranial Doppler ultrasound to record middle cerebral artery velocity (MCAv), a surrogate measure of CBF, during moderate-intensity exercise in sedentary, cognitively-normal older adults (N = 90). A multiple linear regression model (F(4, 85) = 3.21, p = 0.02) showed self-reported omega-3 supplement use significantly moderated the association between age and mean exercising MCAv in these individuals (p = 0.01). Older age was associated with lower exercising MCAv in the group not taking omega-3 supplements, while exercising MCAv showed no decline with increasing age in the group who reported omega-3 supplement use. These findings suggest omega-3 supplementation may have an important role in the preservation of CBF with aging.

Subject Areas

vascular; omega-3; exercise; cerebral blood flow; middle cerebral artery; supplements

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