Preprint Short Note Version 3 Preserved in Portico This version is not peer-reviewed

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

Version 1 : Received: 19 February 2020 / Approved: 20 February 2020 / Online: 20 February 2020 (07:07:36 CET)
Version 2 : Received: 26 February 2020 / Approved: 29 February 2020 / Online: 29 February 2020 (11:24:04 CET)
Version 3 : Received: 19 March 2020 / Approved: 20 March 2020 / Online: 20 March 2020 (09:14:58 CET)
Version 4 : Received: 28 March 2020 / Approved: 30 March 2020 / Online: 30 March 2020 (04:56:42 CEST)
Version 5 : Received: 13 June 2020 / Approved: 14 June 2020 / Online: 14 June 2020 (17:43:37 CEST)

How to cite: Wan, Y.; Yan, S.; Zhang, Y.; An, S.; Yang, K.; Xu, H.; Gan, T.; Cao, W.; Liu, Q. The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus. Preprints 2020, 2020020289 (doi: 10.20944/preprints202002.0289.v3). Wan, Y.; Yan, S.; Zhang, Y.; An, S.; Yang, K.; Xu, H.; Gan, T.; Cao, W.; Liu, Q. The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus. Preprints 2020, 2020020289 (doi: 10.20944/preprints202002.0289.v3).

Abstract

The current pneumonia epidemic in China could evolve into a pandemic on a global scale if not effectively contained. The SARS-CoV-2 possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in SARS-CoV-2. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. As the content of essential amino acids in the open reading frame of SARS-CoV-2 reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Furthermore, several proteins of SARS-CoV-2 possess high valine plus glycine content which is implicated in heart disease, justifying the aforementioned approaches.

Subject Areas

COVID-19; proton affinity; calcium oxalate; isoleucine; valine; glycine; prophylactic approach

Comments (1)

Comment 1
Received: 20 March 2020
Commenter: Qiuyun Liu
Commenter's Conflict of Interests: Author
Comment: Latest viral name is adopted in the title and main context. Table 3 and Figure 1 are added. Conclusion is added. Author order is changed. Abstract is modified.
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