Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV

Version 1 : Received: 10 February 2020 / Approved: 10 February 2020 / Online: 10 February 2020 (15:29:34 CET)
Version 2 : Received: 17 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (11:52:25 CET)

How to cite: He, X.; Yue, W.; Yan, J. SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV. Preprints 2020, 2020020132 (doi: 10.20944/preprints202002.0132.v1). He, X.; Yue, W.; Yan, J. SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV. Preprints 2020, 2020020132 (doi: 10.20944/preprints202002.0132.v1).

Abstract

The rapid development of 2019-2020 Wuhan seafood market pneumonia currently posed a major public health concern in China. Genome sequencing identified a novel beta-coronavirus closely related to SARS-CoV, named 2019-nCoV by WHO, as the cause of this pandemic disease. Viruses with single stranded RNA genome are prone to evolve quickly by accumulation of mutations, such as SNV, INDEL and cross viral recombination, aiding fast transmission among hosts and cross species. Here we collected related genome sequences and investigated variations shared by different strains of 2019-nCoV, identified reoccurrence of SNV mutations in clusters of patients, an indication of rapid evolution of 2019-nCoV at the transmission from animal host to human. The information collected herein would help to understand the dynamics of current pandemic.

Subject Areas

2019-nCoV; novel corona virus; Wuhan pneumonia

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