Working Paper Hypothesis Version 1 This version is not peer-reviewed

Potential Natural Compounds for Preventing 2019-nCoV Infection

Version 1 : Received: 28 January 2020 / Approved: 30 January 2020 / Online: 30 January 2020 (03:06:07 CET)
Version 2 : Received: 16 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (04:56:54 CET)
Version 3 : Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (05:09:22 CET)

How to cite: Chen, H.; Du, Q. Potential Natural Compounds for Preventing 2019-nCoV Infection. Preprints 2020, 2020010358 Chen, H.; Du, Q. Potential Natural Compounds for Preventing 2019-nCoV Infection. Preprints 2020, 2020010358

Abstract

2019-nCoV, a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), which is the same as the host receptor of SARS-CoV. Targeting ACE2 holds the promise for preventing 2019-nCoV infection. Chinese Medicine herbs could be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we summarize several active compounds including baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that could have potential anti-2019-nCoV effects, and we conduct molecular docking to predict their capacity for binding ACE2, which may subsequently prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV.

Subject Areas

2019-nCov; Baicalin; Scutellarin; Hesperetin; Nicotianamine; Glycyrrhizin

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