Submitted:
28 January 2020
Posted:
30 January 2020
Read the latest preprint version here
Preprints on COVID-19 and SARS-CoV-2
Abstract
2019-nCoV, a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), which is the same as the host receptor of SARS-CoV. Targeting ACE2 holds the promise for preventing 2019-nCoV infection. Chinese Medicine herbs could be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we summarize several active compounds including baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that could have potential anti-2019-nCoV effects, and we conduct molecular docking to predict their capacity for binding ACE2, which may subsequently prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV.
Keywords:
2019-nCov
; Baicalin
; Scutellarin
; Hesperetin
; Nicotianamine
; Glycyrrhizin
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
