Working Paper Hypothesis Version 1 This version is not peer-reviewed

Potential Natural Compounds for Preventing 2019-nCoV Infection

Version 1 : Received: 28 January 2020 / Approved: 30 January 2020 / Online: 30 January 2020 (03:06:07 CET)
Version 2 : Received: 16 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (04:56:54 CET)
Version 3 : Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (05:09:22 CET)

How to cite: Chen, H.; Du, Q. Potential Natural Compounds for Preventing 2019-nCoV Infection. Preprints 2020, 2020010358 Chen, H.; Du, Q. Potential Natural Compounds for Preventing 2019-nCoV Infection. Preprints 2020, 2020010358


2019-nCoV, a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), which is the same as the host receptor of SARS-CoV. Targeting ACE2 holds the promise for preventing 2019-nCoV infection. Chinese Medicine herbs could be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we summarize several active compounds including baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that could have potential anti-2019-nCoV effects, and we conduct molecular docking to predict their capacity for binding ACE2, which may subsequently prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV.


2019-nCov; Baicalin; Scutellarin; Hesperetin; Nicotianamine; Glycyrrhizin


Medicine and Pharmacology, Pharmacy

Comments (0)

Comment 1
Received: 24 March 2020
Commenter: David Smith
The commenter has declared there is no conflict of interests.
Comment: Thank you so much for your work. Both of you have shown some incredible knowledge and insightfulness.
I have passed on the results of your research to as many people who might understand it and based upon your research have at least partially instituted the regimine your research has proven beneficial. Now in my mind you have already pointed out by the ACE2 involvement with SARS-CoV 1 and 2 it then becomes fairly easy to fit the rest of the pieces of the puzzle.

Looking at the morbidity charts country by country tells a very interesting story particularly when you factor in the the other conditions that already affected the deceased and how important that everyone be aware of that link which is statistically undeniable.

Now just something else I have been able to glean from my paper research on the web. It appears that the causative factor in these deaths is not the action of the virus but rather the immune response it mounts by the above mentioned group. The "cytokine storm" is what attacks the lungs and kidneys which ultimately is the cause of death. This explains why so many cases are asymptomatic.

OK back to your brilliant research. Now if one were to extrapolate those morbidity figures and do some real science based on what we already know from your work, what's the common denominator? Rather than answer that question let me pose a fact. Some High Blood Pressure medication (the overwhelming morbidity factor) and some Type 2 Diabetes medication (the #2 common factor) can both be successfully treated with ACE Inhibitor based medications.
I'll let people take it from there. I did do work with autoimmune disorders for a while. A superinfection of SARS-CoV 2 could produce a massive cytokine response. To support this a physician in Italy successfully treated a severely ill patient with an RA drug with great success. So much so the Chinese Government has approved the drug as a treatment for SARS-CoV 2. Some preliminary rumors in the US have had physicians treat with Cortisone with the same results.

So anyway I am probably not telling you anything you don't know. I am somewhat confused why this hasn't been divulged to at least the healthcare professionals. I understand you can't have everyone on ACE inhibitors just quit taking them. The consequences would be dire. You almost have to wonder what affect a vaccine would have on these same group of compromised people depending on the type of vaccine that would be produced. On the other hand what other solution is there? They are treating this in the US like the virus will just magically disappear.

Thanks for taking the time to read this. I would be honored if you could take the time for a response.
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