Preprint Hypothesis Version 3 Preserved in Portico This version is not peer-reviewed

Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection

Version 1 : Received: 28 January 2020 / Approved: 30 January 2020 / Online: 30 January 2020 (03:06:07 CET)
Version 2 : Received: 16 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (04:56:54 CET)
Version 3 : Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (05:09:22 CET)

How to cite: Chen, H.; Du, Q. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints 2020, 2020010358 (doi: 10.20944/preprints202001.0358.v3). Chen, H.; Du, Q. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints 2020, 2020010358 (doi: 10.20944/preprints202001.0358.v3).

Abstract

SARS-CoV-2 (2019-nCoV), a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), is the same as the host receptor for SARS-CoV. Targeting ACE2 holds the promise for preventing and inhibiting 2019-nCoV infection. Chinese Medicine herbs could be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we summarize several active compounds, including baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that could have potential anti-2019-nCoV effects. We conduct molecular docking to predict their capacity for binding ACE2, which may prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV.

Subject Areas

SARS-CoV-2 (2019-nCoV); Baicalin; Scutellarin; Hesperetin; Nicotianamine; Glycyrrhizin

Comments (1)

Comment 1
Received: 10 March 2020
Commenter: Hansen Chen
Commenter's Conflict of Interests: Author
Comment: We updated the detail of ACE2 receptor and the detail about the binding of those natural compounds to ACE2 receptor
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