Version 1
: Received: 28 January 2020 / Approved: 30 January 2020 / Online: 30 January 2020 (03:06:07 CET)
Version 2
: Received: 16 February 2020 / Approved: 18 February 2020 / Online: 18 February 2020 (04:56:54 CET)
Version 3
: Received: 9 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (05:09:22 CET)
How to cite:
Chen, H.; Du, Q. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints2020, 2020010358. https://doi.org/10.20944/preprints202001.0358.v3
Chen, H.; Du, Q. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints 2020, 2020010358. https://doi.org/10.20944/preprints202001.0358.v3
Chen, H.; Du, Q. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints2020, 2020010358. https://doi.org/10.20944/preprints202001.0358.v3
APA Style
Chen, H., & Du, Q. (2020). Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection. Preprints. https://doi.org/10.20944/preprints202001.0358.v3
Chicago/Turabian Style
Chen, H. and Qiaohui Du. 2020 "Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection" Preprints. https://doi.org/10.20944/preprints202001.0358.v3
Abstract
SARS-CoV-2 (2019-nCoV), a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), is the same as the host receptor for SARS-CoV. Targeting ACE2 holds the promise for preventing and inhibiting 2019-nCoV infection. Chinese Medicine herbs could be a valuable pool for identifying active compounds for treating infection of 2019-nCoV. In this study, we summarize several active compounds, including baicalin, Scutellarin, Hesperetin, Nicotianamine and glycyrrhizin that could have potential anti-2019-nCoV effects. We conduct molecular docking to predict their capacity for binding ACE2, which may prevent the 2019-nCoV infection. We propose that these selected compounds worth further investigation for preventing 2019-nCoV.
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Hansen Chen
Commenter's Conflict of Interests: Author