Summary: Chemical Modulation of Circadian Rhythms and Assessment of Cellular Behavior via Indirubin and Derivatives

Hui-Hsien Lin; Kelly L. Robertson; Sujeewa S. Lellupitiyage Don; Stephanie R. Taylor; Michelle E. Farkas

doi:10.20944/preprints202001.0292.v1

How to cite: Lin, H.; Robertson, K.L.; Lellupitiyage Don, S.S.; Taylor, S.R.; Farkas, M.E. Summary: Chemical Modulation of Circadian Rhythms and Assessment of Cellular Behavior via Indirubin and Derivatives. Preprints 2020, 2020010292 (doi: 10.20944/preprints202001.0292.v1). Lin, H.; Robertson, K.L.; Lellupitiyage Don, S.S.; Taylor, S.R.; Farkas, M.E. Summary: Chemical Modulation of Circadian Rhythms and Assessment of Cellular Behavior via Indirubin and Derivatives. Preprints 2020, 2020010292 (doi: 10.20944/preprints202001.0292.v1).

Abstract

We present a summary of our protocol for employment of small-molecule circadian rhythm modulators. The abilities of compounds to affect oscillations have received significant attention. We outline assessments of circadian changes using indirubin-3’-oxime (IO), 5-iodo-indirubin-3’-oxime (5I-IO), and 5-sulfonic acid-indirubin-3’-oxime (5SA-IO), analyzing effects on Bmal1 and Per2 oscillations and oncogenic features.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Summary: Chemical Modulation of Circadian Rhythms and Assessment of Cellular Behavior via Indirubin and Derivatives

Abstract

Subject Areas

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