Preprint Review Version 1 This version is not peer-reviewed

A Decade of Antifungal Leads from Natural Products

Version 1 : Received: 29 November 2019 / Approved: 30 November 2019 / Online: 30 November 2019 (11:30:19 CET)

A peer-reviewed article of this Preprint also exists.

Aldholmi, M.; Marchand, P.; Ourliac-Garnier, I.; Le Pape, P.; Ganesan, A. A Decade of Antifungal Leads from Natural Products: 2010–2019. Pharmaceuticals 2019, 12, 182. Aldholmi, M.; Marchand, P.; Ourliac-Garnier, I.; Le Pape, P.; Ganesan, A. A Decade of Antifungal Leads from Natural Products: 2010–2019. Pharmaceuticals 2019, 12, 182.

Journal reference: Pharmaceuticals 2019, 12, 182
DOI: 10.3390/ph12040182

Abstract

In this review, we discuss novel natural products discovered within the last decade that are reported to have antifungal activity against pathogenic species. Nearly a hundred natural products were identified that originate from bacteria, alga, fungi, sponges and plants. Fungi were the most prolific source of antifungal compounds discovered during the period of review. The structural diversity of these antifungal leads encompasses all the major classes of natural products including polyketides, shikimate metabolites, terpenoids, alkaloids and peptides.

Subject Areas

fungal pathogens; antifungal agents; natural products

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