Version 1
: Received: 15 November 2019 / Approved: 18 November 2019 / Online: 18 November 2019 (06:34:56 CET)
Version 2
: Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (03:26:40 CET)
How to cite:
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints2019, 2019110213
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints 2019, 2019110213
Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints2019, 2019110213
APA Style
Kwon, S., Tisserant, C., Tulinski, M., Weiberg, A., & Feldbrügge, M. (2020). Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints. https://doi.org/
Chicago/Turabian Style
Kwon, S., Arne Weiberg and Michael Feldbrügge. 2020 "Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport" Preprints. https://doi.org/
Abstract
Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the RNA cargo and mechanistic details of transport via two inter-related sets of organelles: endosomes and extracellular vesicles for intra- and intercellular RNA transfer. Simultaneous transport and translation of messenger RNAs (mRNAs) on the surface of shuttling endosomes is a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail the endosomal mRNA transport machinery components and mRNA targets of the core RNA-binding protein Rrm4. Extracellular vesicles (EVs) are newly garnering interest as mediators of intercellular communication, especially between pathogenic fungi and their hosts. Landmark studies in plant-fungus interactions indicate EVs as a means of delivering various cargos, most notably small RNAs (sRNAs), for cross-kingdom RNA interference. Recent advances and implications of the nascent field of fungal EVs are discussed and potential links between endosomal and EV-mediated RNA transport are proposed.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Michael Feldbrügge
Commenter's Conflict of Interests: Author