Working Paper Review Version 2 This version is not peer-reviewed

Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport

Version 1 : Received: 15 November 2019 / Approved: 18 November 2019 / Online: 18 November 2019 (06:34:56 CET)
Version 2 : Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (03:26:40 CET)

How to cite: Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints 2019, 2019110213 Kwon, S.; Tisserant, C.; Tulinski, M.; Weiberg, A.; Feldbrügge, M. Inside-Out: From Endosomes to Extracellular Vesicles in Fungal RNA Transport. Preprints 2019, 2019110213

Abstract

Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the RNA cargo and mechanistic details of transport via two inter-related sets of organelles: endosomes and extracellular vesicles for intra- and intercellular RNA transfer. Simultaneous transport and translation of messenger RNAs (mRNAs) on the surface of shuttling endosomes is a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail the endosomal mRNA transport machinery components and mRNA targets of the core RNA-binding protein Rrm4. Extracellular vesicles (EVs) are newly garnering interest as mediators of intercellular communication, especially between pathogenic fungi and their hosts. Landmark studies in plant-fungus interactions indicate EVs as a means of delivering various cargos, most notably small RNAs (sRNAs), for cross-kingdom RNA interference. Recent advances and implications of the nascent field of fungal EVs are discussed and potential links between endosomal and EV-mediated RNA transport are proposed.

Subject Areas

endosome; exosome; extracellular vesicles; fungal RNA biology; membrane trafficking; RNA transport; RNA recognition motif

Comments (1)

Comment 1
Received: 21 January 2020
Commenter: Michael Feldbrügge
Commenter's Conflict of Interests: Author
Comment: Revised version accepted for publication at Fungal Biol Rev
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