Preprint Article Version 2 This version is not peer-reviewed

Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast

Version 1 : Received: 2 September 2019 / Approved: 3 September 2019 / Online: 3 September 2019 (04:28:15 CEST)
Version 2 : Received: 15 October 2019 / Approved: 16 October 2019 / Online: 16 October 2019 (09:23:03 CEST)
Version 3 : Received: 11 November 2019 / Approved: 13 November 2019 / Online: 13 November 2019 (11:02:35 CET)

How to cite: Lin, Y.; Lin, Y.; Chan, S.; Chung, Y.; Lin, Y.; Kan, K.; Yu, C. Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast. Preprints 2019, 2019090028 (doi: 10.20944/preprints201909.0028.v2). Lin, Y.; Lin, Y.; Chan, S.; Chung, Y.; Lin, Y.; Kan, K.; Yu, C. Anti Cutaneous Aging Effect of Red Djulis (Chenopodium formosanum) Extract on Gene Expression of Human Dermal Fibroblast. Preprints 2019, 2019090028 (doi: 10.20944/preprints201909.0028.v2).

Abstract

Red djulis (Chenopodium formosanum) is a native cereal plant in Taiwan; it contains abundant polyphenols, betalian and dietary fiber. The appearance of red djulis is bright red. Therefore, it is also called the “ruby of cereals”. The antioxidative activity of red djulis extract is well-understood. However, the antiaging function still remains unclear. This study examined the potential of red djulis extract for enhancing collagen secretion and preventing cutaneous aging using red djulis extracts. The red djulis extracts are comprised of an abundant active component that can effectively enhance the ability of collagen secretion of dermal fibroblasts, prevent the glycation of collagen and resist the damage of ultraviolet light exposure. After fibroblast treatment with red djulis extracts, TGM1, KRT1, KRT10 and SOD2 genes were up-regulated significantly by 2.3, 4.3, 4.4 and 27.3 times, respectively, compared to those of the control group. Additionally, it can increase COL1A2 gene expression by 43% and decrease MMP9 gene expression 33%. Therefore, it was demonstrated that red djulis extracts affect gene expressions related to the skin barrier, antioxidation and collagen. Moreover, we found positive effects on skin barrier integrity, endogenous antioxidant activity and skin collagen-preservation. The preparation of the red djulis extracts is environmental friendly and can promote the economic value of Chenopodium formosanum; thus, the proposed extract is suitable for applications in the development of food products, especially beverages, skin care and cosmetic products.

Subject Areas

Chenopodium formosanum; human dermal fibroblast; UV exposure; antioxidant activity; anti-aging; red djulis

Comments (1)

Comment 1
Received: 16 October 2019
Commenter: Yung-Kai LIN
Commenter's Conflict of Interests: Author
Comment: -
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