Preprint Article Version 1 This version is not peer-reviewed

The ZIKA Virus Controls Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins

Version 1 : Received: 13 August 2019 / Approved: 15 August 2019 / Online: 15 August 2019 (07:39:04 CEST)
Version 2 : Received: 16 September 2019 / Approved: 18 September 2019 / Online: 18 September 2019 (03:05:26 CEST)

How to cite: Turpin, J.; Frumence, E.; Desprès, P.; Viranaïcken, W.; Krejbich-Trotot, P. The ZIKA Virus Controls Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins. Preprints 2019, 2019080167 (doi: 10.20944/preprints201908.0167.v1). Turpin, J.; Frumence, E.; Desprès, P.; Viranaïcken, W.; Krejbich-Trotot, P. The ZIKA Virus Controls Cell Death through the Anti-Apoptotic Bcl-2 Family Proteins. Preprints 2019, 2019080167 (doi: 10.20944/preprints201908.0167.v1).

Abstract

Zika virus (ZIKV) is an emerging human mosquito-transmitted pathogen of global concern, known to cause severe complications such as congenital defects and neurological disorders in adults. ZIKV infection is associated with cell death. However, previous studies suggest that the virally-induced apoptosis occurs at a slower rate compared to the course of viral production. In this present study, we investigated the capacity of ZIKV to delay host cell apoptosis. We provide evidence that ZIKV has the ability to control programmed cell death whether it is intrinsically or extrinsically induced. In cells expressing viral replicon-type constructions, we show that this control is achieved through replication. Finally, our work highlights an important role for anti-apoptotic Bcl-2 family protein in the ability of ZIKV to control apoptotic pathways, avoiding premature cell death and thereby promoting virus replication in the host-cell.

Subject Areas

Zika virus; programmed cell death; viral replication; Bcl-2 protein family

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