Preprint Article Version 1 This version is not peer-reviewed

Green Synthesis of Silver Nanoparticles Using Scindapsus officinalis (Gajpipli): In-Vitro Cytotoxic Activity Against HepG-2 & MCF-7 Cancer Cell Lines

Version 1 : Received: 10 August 2019 / Approved: 13 August 2019 / Online: 13 August 2019 (09:10:03 CEST)

How to cite: Pathak, M.; Kumar, V.; Pathak, P.; Majee, R.; Ramteke, P.W.; Verma, A. Green Synthesis of Silver Nanoparticles Using Scindapsus officinalis (Gajpipli): In-Vitro Cytotoxic Activity Against HepG-2 & MCF-7 Cancer Cell Lines. Preprints 2019, 2019080118 (doi: 10.20944/preprints201908.0118.v1). Pathak, M.; Kumar, V.; Pathak, P.; Majee, R.; Ramteke, P.W.; Verma, A. Green Synthesis of Silver Nanoparticles Using Scindapsus officinalis (Gajpipli): In-Vitro Cytotoxic Activity Against HepG-2 & MCF-7 Cancer Cell Lines. Preprints 2019, 2019080118 (doi: 10.20944/preprints201908.0118.v1).

Abstract

Background: Green synthesis of silver (Ag) nanoparticle was performed with the fruit extract of Scindapsus officinalis and test against HepG-2, MCF-7 cancer cell lines. These biosynthesized metal nanoparticles have a potential of therapeutic use as an alternative medicine for the treatment of hepatic & breast cancer cases. Results : AgNPs were identified by change of color & their absobtion at 340 nm measured by UV-visible spectroscopy, FTIR spectral analysis confirmed phenolic compounds presence, morphology & size visualized in SEM, TEM used for determination of size, shape & light scattering analysis. Synthesized silver nanoparticles were spherical in shape and size less than 50 nm. XRD analysis was affirmed the crystalline nature of metal particles. In-vitro cytotoxic result showed an excellent IC50 value of 155.81μg/ml and 114.74 μg/ml against HepG-2 & MCF-7 cell lines. Conclusion: The current study reveals green synthesized AgNPs possess high cytotoxic action against HepG-2 & MCF-7 cell lines which suggested the use of silver nanoparticles as a medicine to treat hepatic & breast cancer.

Subject Areas

Silver nanoparticles, Scindapsus officinalis, MTT assay, HepG-2, MCF-7

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