Working Paper Article Version 1 This version is not peer-reviewed

Changes of Conformation in Albumin Protein with Temperature

Version 1 : Received: 6 August 2019 / Approved: 7 August 2019 / Online: 7 August 2019 (09:59:10 CEST)

How to cite: Weber, P.; Bełdowski, P.; DOMINO, K.A.; Gadomski, A. Changes of Conformation in Albumin Protein with Temperature. Preprints 2019, 2019080092 Weber, P.; Bełdowski, P.; DOMINO, K.A.; Gadomski, A. Changes of Conformation in Albumin Protein with Temperature. Preprints 2019, 2019080092

Abstract

We study a conformation of an albumin protein in the temperature range of 300K-315K, i.e. in the physiological range of temperature. Using simulations we calculate values of two backbone angles, that carry most of information about positioning of the protein chain in a conformational space. Given these, we calculate energy components of such protein. Further, using the Flory theory we determine the temperature in which investigated albumin chain model is closest to the free joined chain model. Near the Flory temperature, we study energy components and the conformational entropy, both derived from two angles that reflect most of the chain dynamics in a conformational space. We show that the conformational entropy is an oscillating function of time in considered range of temperature. Our finding is that, the only regular oscillation pattern appears near the Flory temperature.

Subject Areas

conformation of protein; albumin protein; non-gaussian chain

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