Preprint Review Version 1 This version is not peer-reviewed

Omega 3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials

Version 1 : Received: 24 July 2019 / Approved: 25 July 2019 / Online: 25 July 2019 (11:38:57 CEST)

A peer-reviewed article of this Preprint also exists.

Avallone, R.; Vitale, G.; Bertolotti, M. Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials. Int. J. Mol. Sci. 2019, 20, 4256. Avallone, R.; Vitale, G.; Bertolotti, M. Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials. Int. J. Mol. Sci. 2019, 20, 4256.

Journal reference: Int. J. Mol. Sci. 2019, 20, 4256
DOI: 10.3390/ijms20174256

Abstract

A nutritional approach could be a promising strategy to prevent or slow the progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease, since there is no effective therapy for these diseases so far. The beneficial effects of omega-3 fatty acids are now well established by a plethora of studies through their involvement in multiple biochemical functions, including synthesis of antinflammatory mediators, cell membrane fluidity, intracellular signalling and gene expression. This systematic review will consider epidemiological studies and clinical trials that assessed the impact of supplementation or dietary intake of omega-3 polyunsaturated fatty acids on neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases. Indeed, treatment with omega-3 fatty acids, being safe and well tolerated, represent a valuable and biologically plausible tool in the management of neurodegenerative diseases in their early stages.

Subject Areas

omega-3 polyunsaturated fatty acids; Parkinson’s disease; Alzheimer’s disease; clinical trials

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