He, X.; Yang, L.; Wang, Z.; Jing, G.; Huang, R.; Xu, Z.; Wang, S.; Zhu, R. Indispensable CBR1 in Major Depressive Disorder Therapy by Functionalized Solid Lipid Nanoparticles. Preprints2019, 2019070066
APA Style
He, X., Yang, L., Wang, Z., Jing, G., Huang, R., Xu, Z., Wang, S., & Zhu, R. (2019). Indispensable CBR1 in Major Depressive Disorder Therapy by Functionalized Solid Lipid Nanoparticles. Preprints. https://doi.org/
Chicago/Turabian Style
He, X., Shilong Wang and Rongrong Zhu. 2019 "Indispensable CBR1 in Major Depressive Disorder Therapy by Functionalized Solid Lipid Nanoparticles" Preprints. https://doi.org/
Abstract
Nanoparticles offer available tools for MDD research. In this assay, we applied CBR1 (cannabinoid receptor 1) knockout (CB1-/-) mice to study whether functionalized solid lipid nanoparticles loading with curcumin and dexanabinol (Cur/SLNs-HU-211) exhibited anti-depressant outcomes through CBR1. Wild-type (CB1+/+) animals together with CBR1 knockout (CB1-/-) animals received daily injections of Corticosterone (CORT) for 3 weeks to obtain MDD mice model, and then the therapeutic action of Cur/SLNs-HU-211 were evaluated, respectively. Our work show that Cur/SLNs-HU-211 nanoparticles in the existence of CBR1 facilitate an efficient motor function improvement in CORT-induced MDD mice model. Cur/SLNs-HU-211 nanoparticles alleviated symptoms on CB1+/+ MDD mice and resulted in dopamine and norepinephrine recovery following CORT-induced neurotoxicity. In conclusion, the possible mechanisms underlying the antidepressant effect of Cur/SLNs-HU-211 might be the induction of CB1 expression and downstream RASGEF1C and Egr1 expression, together with a significantly upregulation of neuron-specific genes in CB1+/+ mice only. In conclusion, CBR1 is necessary during the process of antidepressant activities of Cur/SLNs-HU-211 nanoparticles. This study confirms that Cur/SLNs-HU-211 nanoparticles based CBR1 in vivo targeting would be a potentially feasible and safe way to motivate future therapeutic strategies of Major Depressive Disorder.
Keywords
major depressive disorder; functionalized solid lipid nanoparticles; CBR1
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
