Preprint Article Version 1 This version is not peer-reviewed

Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination

Version 1 : Received: 27 June 2019 / Approved: 28 June 2019 / Online: 28 June 2019 (07:42:18 CEST)

A peer-reviewed article of this Preprint also exists.

Oda, K.; Okada, H.; Suzuki, A.; Tomita, H.; Kobayashi, R.; Sumi, K.; Suzuki, K.; Takada, C.; Ishihara, T.; Suzuki, K.; Kano, S.; Kondo, K.; Iwashita, Y.; Yano, H.; Zaikokuji, R.; Sampei, S.; Fukuta, T.; Kitagawa, Y.; Okamoto, H.; Watanabe, T.; Kawaguchi, T.; Kojima, T.; Deguchi, F.; Miyazaki, N.; Yamada, N.; Doi, T.; Yoshida, T.; Ushikoshi, H.; Yoshida, S.; Takemura, G.; Ogura, S. Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination. J. Clin. Med. 2019, 8, 1320. Oda, K.; Okada, H.; Suzuki, A.; Tomita, H.; Kobayashi, R.; Sumi, K.; Suzuki, K.; Takada, C.; Ishihara, T.; Suzuki, K.; Kano, S.; Kondo, K.; Iwashita, Y.; Yano, H.; Zaikokuji, R.; Sampei, S.; Fukuta, T.; Kitagawa, Y.; Okamoto, H.; Watanabe, T.; Kawaguchi, T.; Kojima, T.; Deguchi, F.; Miyazaki, N.; Yamada, N.; Doi, T.; Yoshida, T.; Ushikoshi, H.; Yoshida, S.; Takemura, G.; Ogura, S. Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination. J. Clin. Med. 2019, 8, 1320.

Journal reference: J. Clin. Med. 2019, 8, 1320
DOI: 10.3390/jcm8091320

Abstract

Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018, to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (p = 0.016), aspartic aminotransferase concentration (AST, p = 0.020), blood urea nitrogen concentration (BUN, p = 0.013), triglyceride concentration (p < 0.001), and hematocrit (p = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.

Subject Areas

endothelial disorders; glycocalyx injury; syndecan-1; nonlinear regression

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