Version 1
: Received: 19 June 2019 / Approved: 21 June 2019 / Online: 21 June 2019 (08:23:35 CEST)
How to cite:
Vodyanoy, V.; Pustovyy, O.; Globa, L.; Kulesza Jr, R.J.; Sorokulova, I. Hemmule: A Novel Structure with the Properties of the Stem Cell Niche. Preprints2019, 2019060206. https://doi.org/10.20944/preprints201906.0206.v1
Vodyanoy, V.; Pustovyy, O.; Globa, L.; Kulesza Jr, R.J.; Sorokulova, I. Hemmule: A Novel Structure with the Properties of the Stem Cell Niche. Preprints 2019, 2019060206. https://doi.org/10.20944/preprints201906.0206.v1
Vodyanoy, V.; Pustovyy, O.; Globa, L.; Kulesza Jr, R.J.; Sorokulova, I. Hemmule: A Novel Structure with the Properties of the Stem Cell Niche. Preprints2019, 2019060206. https://doi.org/10.20944/preprints201906.0206.v1
APA Style
Vodyanoy, V., Pustovyy, O., Globa, L., Kulesza Jr, R.J., & Sorokulova, I. (2019). Hemmule: A Novel Structure with the Properties of the Stem Cell Niche. Preprints. https://doi.org/10.20944/preprints201906.0206.v1
Chicago/Turabian Style
Vodyanoy, V., Randy J Kulesza Jr and Iryna Sorokulova. 2019 "Hemmule: A Novel Structure with the Properties of the Stem Cell Niche" Preprints. https://doi.org/10.20944/preprints201906.0206.v1
Abstract
Stem cells are nurtured and regulated by a specialized microenvironment known as stem cell niche. While the functions of the niches are well defined, their structure and location remain unclear. We have identified in rat bone marrow, the seat of hematopoietic stem cells, extensively vascularized node-like compartments that fit the requirements for stem cell niche and which we called hemmules. Hemmules are round or oval structures of about one millimeter in diameter that are surrounded by a fine capsule, have afferent and efferent vessels, are filled with the extracellular matrix and mesenchymal, hematopoietic, endothelial stem cells, and contain cells of the megakaryocyte family, which are known for homeostatic quiescence and contribution to the bone marrow environment. We propose that hemmules are the long sought hematopoietic stem cell niches and that they are prototypical of stem cell niches in other organs.
Keywords
vascular; node; mesenchymal; hematopoietic; endothelial; megakaryocyte; quiescence; bone marrow
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
