Version 1
: Received: 19 April 2019 / Approved: 23 April 2019 / Online: 23 April 2019 (11:06:29 CEST)
Version 2
: Received: 23 April 2019 / Approved: 24 April 2019 / Online: 24 April 2019 (12:20:07 CEST)
Version 3
: Received: 20 September 2019 / Approved: 23 September 2019 / Online: 23 September 2019 (10:16:40 CEST)
How to cite:
Robinson, J. The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway. Preprints2019, 2019040254 (doi: 10.20944/preprints201904.0254.v1).
Robinson, J. The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway. Preprints 2019, 2019040254 (doi: 10.20944/preprints201904.0254.v1).
Cite as:
Robinson, J. The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway. Preprints2019, 2019040254 (doi: 10.20944/preprints201904.0254.v1).
Robinson, J. The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway. Preprints 2019, 2019040254 (doi: 10.20944/preprints201904.0254.v1).
Abstract
Subsidiary to detection and assignment of novel microRNAs in non-model taxa, it is standard to identify and compare genomic or transcript sequence of Drosha and Pasha. Detection of both (1) bona fide microRNAs and (2) presence of Drosha/Pasha orthologs is often assumed to represent a functional canonical eumetazoan microRNA biogenesis pathway. However, this is not often experimentally confirmed in non-model taxa, and therefore the assumption is not necessarily valid. Below I describe several lines of evidence for this assertion.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.