The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway

Jeffrey Robinson

doi:10.20944/preprints201904.0254.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 19 April 2019 / Approved: 23 April 2019 / Online: 23 April 2019 (11:06:29 CEST)
Version 2 : Received: 23 April 2019 / Approved: 24 April 2019 / Online: 24 April 2019 (12:20:07 CEST)
Version 3 : Received: 20 September 2019 / Approved: 23 September 2019 / Online: 23 September 2019 (10:16:40 CEST)

Subsidiary to detection and assignment of novel microRNAs in non-model taxa, it is standard to identify and compare genomic or transcript sequence of Drosha and Pasha. Detection of both (1) bona fide microRNAs and (2) presence of Drosha/Pasha orthologs is often assumed to represent a functional canonical eumetazoan microRNA biogenesis pathway. However, this is not often experimentally confirmed in non-model taxa, and therefore the assumption is not necessarily valid. Below I describe several lines of evidence for this assertion.

Microprocessor, miRNA, Drosha, Pasha, miRNA biogenesis pathway, Holozoa, Metazoa, RNA interference, bona fide miRNA, canonical eumetazoan miRNA

Biology and Life Sciences, Biochemistry and Molecular Biology

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The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway

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