The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway

Jeffrey Robinson

doi:10.20944/preprints201904.0254.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 19 April 2019 / Approved: 23 April 2019 / Online: 23 April 2019 (11:06:29 CEST)
Version 2 : Received: 23 April 2019 / Approved: 24 April 2019 / Online: 24 April 2019 (12:20:07 CEST)
Version 3 : Received: 20 September 2019 / Approved: 23 September 2019 / Online: 23 September 2019 (10:16:40 CEST)

Subsidiary to detection and assignment of novel microRNAs in non-model taxa, it is standard to identify and compare genomic or transcript sequence of Drosha and Pasha. Detection of both (1) bona fide microRNAs and (2) presence of Drosha/Pasha orthologs is often assumed to represent a functional canonical eumetazoan microRNA biogenesis pathway. However, this is not often experimentally confirmed in non-model taxa, and therefore the assumption is not necessarily valid. Below I describe several lines of evidence for this assertion.

Microprocessor, miRNA, Drosha, Pasha, miRNA biogenesis pathway, Holozoa, Metazoa, RNA interference, bona fide miRNA, canonical eumetazoan miRNA

LIFE SCIENCES, Molecular Biology

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The Meaning of the Microprocessor: Accounting for Evolution of Structural-Functional Novelty in the Canonical microRNA Biogenesis Pathway

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