Preprint Review Version 4 Preserved in Portico This version is not peer-reviewed

Leishmania Proteomics: An in Silico Perspective

Version 1 : Received: 11 February 2019 / Approved: 13 February 2019 / Online: 13 February 2019 (15:44:08 CET)
Version 2 : Received: 23 May 2019 / Approved: 24 May 2019 / Online: 24 May 2019 (12:49:58 CEST)
Version 3 : Received: 20 February 2020 / Approved: 21 February 2020 / Online: 21 February 2020 (06:57:33 CET)
Version 4 : Received: 28 February 2022 / Approved: 1 March 2022 / Online: 1 March 2022 (12:58:34 CET)
Version 5 : Received: 18 July 2023 / Approved: 19 July 2023 / Online: 19 July 2023 (12:57:15 CEST)
Version 6 : Received: 20 September 2023 / Approved: 21 September 2023 / Online: 22 September 2023 (11:07:35 CEST)

How to cite: Padilla, C.A.; Álvarez, M.J.; Combariza, A.F. Leishmania Proteomics: An in Silico Perspective. Preprints 2019, 2019020122. Padilla, C.A.; Álvarez, M.J.; Combariza, A.F. Leishmania Proteomics: An in Silico Perspective. Preprints 2019, 2019020122.


We report on the state of the art of research on proteins recognized as potential targets for the development of Leishmania treatments and the search of active chemical species. We have reviewed information from experimental in vitro, in vivo, or in silico sources. We classify the gathered information on: a) vector taxonomy and geographical distribution, b) parasite taxonomy, geographical distribution, c) enzymatic function of proteins related to the parasite/host in any of its development states, id. est., oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and cytokines, and d) information on standard and non-standard treatments from bioactive chemical species. Our aim is to provide a much needed reference layout for research efforts aimed to understand the interaction mechanisms of ligand-protein activation/inactivation processes, specifically related to Leishmania, thus, we focus on enzymes known to be part of the biochemical molecular pathways initiated following a Leishmania infectious episode.


Leishmania; leishmaniasis; Theoretical Physics and Chimistry; Molecular Dynamics


Biology and Life Sciences, Biophysics

Comments (1)

Comment 1
Received: 1 March 2022
Commenter: Aldo Combariza
Commenter's Conflict of Interests: Author
Comment: 1. Bibliography updated until 2022
2. Paper structure rearranged
3. New figure included in the overview
4. Overview extended
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