Version 1
: Received: 11 February 2019 / Approved: 13 February 2019 / Online: 13 February 2019 (15:44:08 CET)
Version 2
: Received: 23 May 2019 / Approved: 24 May 2019 / Online: 24 May 2019 (12:49:58 CEST)
Version 3
: Received: 20 February 2020 / Approved: 21 February 2020 / Online: 21 February 2020 (06:57:33 CET)
Version 4
: Received: 28 February 2022 / Approved: 1 March 2022 / Online: 1 March 2022 (12:58:34 CET)
Version 5
: Received: 18 July 2023 / Approved: 19 July 2023 / Online: 19 July 2023 (12:57:15 CEST)
Version 6
: Received: 20 September 2023 / Approved: 21 September 2023 / Online: 22 September 2023 (11:07:35 CEST)
How to cite:
Padilla, C. A.; Alvarez, M. J.; Combariza, A. F. Leishmania Proteomics: An in Silico Perspective. Preprints2019, 2019020122. https://doi.org/10.20944/preprints201902.0122.v2
Padilla, C. A.; Alvarez, M. J.; Combariza, A. F. Leishmania Proteomics: An in Silico Perspective. Preprints 2019, 2019020122. https://doi.org/10.20944/preprints201902.0122.v2
Padilla, C. A.; Alvarez, M. J.; Combariza, A. F. Leishmania Proteomics: An in Silico Perspective. Preprints2019, 2019020122. https://doi.org/10.20944/preprints201902.0122.v2
APA Style
Padilla, C. A., Alvarez, M. J., & Combariza, A. F. (2019). Leishmania Proteomics: An <em>in Silico</em> Perspective. Preprints. https://doi.org/10.20944/preprints201902.0122.v2
Chicago/Turabian Style
Padilla, C. A., Maria J. Alvarez and Aldo F. Combariza. 2019 "Leishmania Proteomics: An <em>in Silico</em> Perspective" Preprints. https://doi.org/10.20944/preprints201902.0122.v2
Abstract
We report on the state of the art of proteins recognized as potential targets for the development of leishmania treatments through the search of biologically active chemical species, either from experimental in vitro, in vivo, or in silico sources. We classify the gathered information, in several ways: vector taxonomy and geographical distribution, leishmania parasite taxonomic and geographical distribution and enzymatic function (oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and cytokines). Our aim is to provide a much needed reference layout for research efforts aimed to understand the background of ligand-protein activation/inactivation processes, in this specific case, related with enzymes known to be part of biochemical cascade reactions initiated following a leishmania infectious episode.
Keywords
computational chemistry; biophysics; proteomics
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
