Preprint Article Version 1 This version is not peer-reviewed

Time Trends in Age at Menarche and Related Non-Communicable Disease Risk During the 20th Century in Mexico

Version 1 : Received: 28 December 2018 / Approved: 31 December 2018 / Online: 31 December 2018 (09:45:35 CET)

A peer-reviewed article of this Preprint also exists.

Petersohn, I.; Zarate-Ortiz, A.G.; Cepeda-Lopez, A.C.; Melse-Boonstra, A. Time Trends in Age at Menarche and Related Non-Communicable Disease Risk during the 20th Century in Mexico. Nutrients 2019, 11, 394. Petersohn, I.; Zarate-Ortiz, A.G.; Cepeda-Lopez, A.C.; Melse-Boonstra, A. Time Trends in Age at Menarche and Related Non-Communicable Disease Risk during the 20th Century in Mexico. Nutrients 2019, 11, 394.

Journal reference: Nutrients 2019, 11, 394
DOI: 10.3390/nu11020394

Abstract

Developed countries have shown a time trend towards a younger age at menarche (AAM), which is associated with increased risk of later obesity and non-communicable diseases. We aimed to assess whether a time trend in AAM with associated disease risk is also present in Mexico. For this, we used data of 30,826 women from the Mexican National Health Survey (2000). Linear and log binomial regression was used for nutritional and disease outcomes, whereas Welch-ANOVA was used to test for a time trend. AAM decreased over time (p < 0.001), with a maximal difference of 0.99 years between the 1920s (13.6 years) and 1980s (12.6 years). AAM (in years) was negatively associated with weight (β = -1.01 kg; 95 % CI -1.006, -1,004) and BMI (β = -1.01 kg/m2; -1.007, -1.006), and positively with height (β = 0.18 cm; 0.112, 0.231). AAM was associated with diabetes (RR = 0.95; 0.93, 0.98) and hypercholesterolemia (RR = 0.93; 0.90, 0.95), but not with hypertension, breast cancer or arthritis. In Mexico, AAM decreased significantly during the 20th century. AAM was inversely associated with adult weight and BMI, and positively with height. Women with a later AAM had a lower risk of diabetes and hypercholesterolemia.

Subject Areas

menarche 1, body mass index 2, height 3, diabetes mellitus 4, non-communicable disease 5.

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