Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

Version 1 : Received: 5 November 2018 / Approved: 8 November 2018 / Online: 8 November 2018 (07:45:28 CET)
Version 2 : Received: 10 November 2018 / Approved: 12 November 2018 / Online: 12 November 2018 (06:48:00 CET)
Version 3 : Received: 28 November 2018 / Approved: 28 November 2018 / Online: 28 November 2018 (07:53:09 CET)
Version 4 : Received: 27 December 2018 / Approved: 28 December 2018 / Online: 28 December 2018 (04:39:00 CET)

A peer-reviewed article of this Preprint also exists.

França, E., Santos Lira, F., Ruaro, M. F., Hirota, V. B., Waziry, P. F., Miranda, M. L. de J., Nicoletti, M. A., Fukushima, A. R., & Caperuto, E. C. (2019). The antioxidant effect of beta-alanine or carnosine supplementation on exercise- induced oxidative stress: a systematic review and meta-analysis, 12(3), 21. https://doi.org/10.22280/revintervol12ed3.452 França, E., Santos Lira, F., Ruaro, M. F., Hirota, V. B., Waziry, P. F., Miranda, M. L. de J., Nicoletti, M. A., Fukushima, A. R., & Caperuto, E. C. (2019). The antioxidant effect of beta-alanine or carnosine supplementation on exercise- induced oxidative stress: a systematic review and meta-analysis, 12(3), 21. https://doi.org/10.22280/revintervol12ed3.452

Journal reference: Revista Intertox de Toxicologia, Risco Ambiental e Sociedade 2019, 12, 57-77
DOI: 10.22280/revintervol12ed3.452

Abstract

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

Subject Areas

beta-alanine; carnosine; oxidative stress; antioxidant

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