Preprint Review Version 1 This version is not peer-reviewed

The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

Version 1 : Received: 5 November 2018 / Approved: 8 November 2018 / Online: 8 November 2018 (07:45:28 CET)
Version 2 : Received: 10 November 2018 / Approved: 12 November 2018 / Online: 12 November 2018 (06:48:00 CET)
Version 3 : Received: 28 November 2018 / Approved: 28 November 2018 / Online: 28 November 2018 (07:53:09 CET)
Version 4 : Received: 27 December 2018 / Approved: 28 December 2018 / Online: 28 December 2018 (04:39:00 CET)

How to cite: de França, E.; Lira, F.S.; Ruaro, M.F.; Hirota, V.B.; Faria Waziry, P.A.; Fukushima, A.R.; Miranda, M.L.D.J.; Caperuto, E.C. The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis. Preprints 2018, 2018110189 (doi: 10.20944/preprints201811.0189.v1). de França, E.; Lira, F.S.; Ruaro, M.F.; Hirota, V.B.; Faria Waziry, P.A.; Fukushima, A.R.; Miranda, M.L.D.J.; Caperuto, E.C. The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis. Preprints 2018, 2018110189 (doi: 10.20944/preprints201811.0189.v1).

Abstract

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.  A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

Subject Areas

beta-alanine; carnosine; oxidative stress; antioxidant

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