Preprint Article Version 1 This version is not peer-reviewed

Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells

Version 1 : Received: 4 November 2018 / Approved: 6 November 2018 / Online: 6 November 2018 (10:55:42 CET)

A peer-reviewed article of this Preprint also exists.

Peng, A.; Qu, X.; Liu, F.; Li, X.; Li, E.; Xie, W. Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells. Mar. Drugs 2018, 16, 470. Peng, A.; Qu, X.; Liu, F.; Li, X.; Li, E.; Xie, W. Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells. Mar. Drugs 2018, 16, 470.

Journal reference: Mar. Drugs 2018, 16, 470
DOI: 10.3390/md16120470

Abstract

Four angucycline glycosides including three new compounds landomycin N (1), galtamycin C (2) and vineomycin D (3), and a known homologue saquayamycin B (4), along with two alkaloids 1-acetyl-β-carboline (5) and indole-3-acetic acid (6), were identified from the fermentation broth of an intertidal sediments derived Streptomyces sp. Their structures were mainly established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC50 values 0.135, 0.033 and 0.244 μM respectively, superior to positive drug doxorubicin. Saquayamycin B treatment to SMMC-7721 cells led to the typical morphological signs of apoptosis in 4',6-diamidino-2-phenylindole (DAPI) staining experiment.

Subject Areas

Streptomyces; angucycline; saquayamycin; cytotoxicity

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