Preprint Article Version 1 This version is not peer-reviewed

Antibacterial Activities of Metabolites from Vitis rotundifolia (Muscadine) Roots against Fish Pathogenic Bacteria

Version 1 : Received: 18 September 2018 / Approved: 19 September 2018 / Online: 19 September 2018 (08:32:39 CEST)

A peer-reviewed article of this Preprint also exists.

Schrader, K.K.; Ibrahim, M.A.; Abd-Alla, H.I.; Cantrell, C.L.; Pasco, D.S. Antibacterial Activities of Metabolites from Vitis rotundifolia (Muscadine) Roots against Fish Pathogenic Bacteria. Molecules 2018, 23, 2761. Schrader, K.K.; Ibrahim, M.A.; Abd-Alla, H.I.; Cantrell, C.L.; Pasco, D.S. Antibacterial Activities of Metabolites from Vitis rotundifolia (Muscadine) Roots against Fish Pathogenic Bacteria. Molecules 2018, 23, 2761.

Journal reference: Molecules 2018, 23, 2761
DOI: 10.3390/molecules23112761

Abstract

Enteric septicemia of catfish, columnaris disease, and streptococcosis, caused by Edwardsiella ictaluri, Flavobacterium columnare, and Streptococcus iniae, respectively, are the most common bacterial diseases of economic significance for the pond-raised channel catfish Ictalurus punctatus industry. Several management practices are used by catfish farmers to prevent large financial losses from these diseases such as the use of commercial antibiotics and other chemicals. In order to discover environmentally benign alternatives, using a rapid bioassay, we evaluated a crude extract from the roots of muscadine Vitis rotundifolia against these fish pathogenic bacteria and determined that the extract was most active against F. columnare. Subsequently, several isolated compounds from the root extract were further evaluated against F. columnare. Among these isolated compounds, (+)-hopeaphenol (2) and (+)-vitisin A (3) were found to be the most active against F. columnare, with 24-h 50% inhibition concentrations of 4.0±0.7 and 7.7±0.6 mg/L, respectively, and minimum inhibitory concentrations of 9.1±0 mg/L for each compound. Efficacy testing of 2 and 3 is necessary to further evaluate the potential for these compounds to be used as antibacterial agents for managing columnaris disease.

Subject Areas

antibacterial; channel catfish; columnaris disease; Flavobacterium columnare; stilbenes; muscadine; pyranoanthocyanin

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