Preprint Article Version 1 This version is not peer-reviewed

Effect of Randomisation to 6-Month Mediterranean versus Low-Fat Diet Intervention on Inflammation and Adiposity in Patients with Coronary Heart Disease; Preliminary Results of the AUSMED Heart Trial

Version 1 : Received: 25 July 2018 / Approved: 26 July 2018 / Online: 26 July 2018 (10:33:01 CEST)

How to cite: Mayr, H.L.; Itsiopoulos, C.; Tierney, A.C.; Kucianski, T.; Radcliffe, J.; Thomas, C.J. Effect of Randomisation to 6-Month Mediterranean versus Low-Fat Diet Intervention on Inflammation and Adiposity in Patients with Coronary Heart Disease; Preliminary Results of the AUSMED Heart Trial. Preprints 2018, 2018070509 (doi: 10.20944/preprints201807.0509.v1). Mayr, H.L.; Itsiopoulos, C.; Tierney, A.C.; Kucianski, T.; Radcliffe, J.; Thomas, C.J. Effect of Randomisation to 6-Month Mediterranean versus Low-Fat Diet Intervention on Inflammation and Adiposity in Patients with Coronary Heart Disease; Preliminary Results of the AUSMED Heart Trial. Preprints 2018, 2018070509 (doi: 10.20944/preprints201807.0509.v1).

Abstract

The Mediterranean diet (MedDiet) is recognised to reduce risk of coronary heart disease (CHD), in part, via its anti-inflammatory properties. Diet efficacy via this mechanism is however unclear in patients with diagnosed CHD. This study aimed to determine the effect of MedDiet versus low-fat diet intervention on inflammatory biomarkers and adiposity in a pilot cohort of Australian patients post coronary event. Participants (62±9 years, 83% male) were randomised to the MedDiet (n=34) or low-fat diet (n=31). At 0-, 3- and 6-months, dietary counselling, anthropometry, body composition (Dual-energy X-ray Absorptiometry) and venepuncture was conducted. Participants adhered well to the MedDiet intervention, however, there were no significant changes in body composition or inflammatory biomarkers hs-C-reactive protein or hs-interleukin-6 in the MedDiet compared to the low-fat diet group after 6-months. Adiponectin, an anti-inflammatory adipokine, tended to increase in response to the MedDiet (+1.1±4.2ng/mL, p=0.11) and decrease in response to the low-fat diet (-0.9±3.3ng/mL, p=0.20). In the pooled cohort, participants with greatest improvement in MedDiet adherence score had significantly lower waist circumference and subcutaneous fat levels at 6-months. A clinically significant effect of the MedDiet on inflammation and adiposity in CHD patients may require a larger sample, adjunct exercise intervention and/or caloric restriction.

Subject Areas

inflammation; coronary disease; mediterranean diet; low-fat diet; C-reactive protein; adiponectin; visceral fat; body composition

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