van Wyk, N.; Kroukamp, H.; Pretorius, I.S. The Smell of Synthetic Biology: Engineering Strategies for Aroma Compound Production in Yeast. Fermentation2018, 4, 54.
van Wyk, N.; Kroukamp, H.; Pretorius, I.S. The Smell of Synthetic Biology: Engineering Strategies for Aroma Compound Production in Yeast. Fermentation 2018, 4, 54.
van Wyk, N.; Kroukamp, H.; Pretorius, I.S. The Smell of Synthetic Biology: Engineering Strategies for Aroma Compound Production in Yeast. Fermentation2018, 4, 54.
van Wyk, N.; Kroukamp, H.; Pretorius, I.S. The Smell of Synthetic Biology: Engineering Strategies for Aroma Compound Production in Yeast. Fermentation 2018, 4, 54.
Abstract
Abstract: Yeast – especially Saccharomyces cerevisiae – have long been a preferred workhorse for the production of numerous recombinant proteins and other metabolites. S. cerevisiae is a noteworthy aroma compound producer, and has also been exploited to produce foreign bioflavour compounds. In the past few years, important strides have been made in unlocking the key elements in the biochemical pathways involved in the production of many aroma compounds. The expression of these biochemical pathways in yeast often involves the manipulation of the host strain to direct the flux towards certain precursors needed for the production of the given aroma compound. This review highlights recent advances in the bioengineering of yeast – including S. cerevisiae – to produce aroma compounds and bioflavours. To capitalise on recent advances in synthetic yeast genomics, this review presents yeast as a significant producer of bioflavours in a fresh context and proposes new directions for combining engineering and biology principles to improve the yield of targeted aroma compounds.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
