Preprint Article Version 1 This version is not peer-reviewed

Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production

Version 1 : Received: 30 May 2018 / Approved: 30 May 2018 / Online: 30 May 2018 (16:42:36 CEST)

How to cite: Cheng, K.; Chang, C.; Lin, Y.; Liu, C.; Zeng, Y.; Lin, Y. Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production. Preprints 2018, 2018050455 (doi: 10.20944/preprints201805.0455.v1). Cheng, K.; Chang, C.; Lin, Y.; Liu, C.; Zeng, Y.; Lin, Y. Secoiridoids from the Seed of Gonocaryum calleryanum and Their Inhibitory Potential on LPS-Induced Tumor Necrosis Factor and Nitric Oxide Production. Preprints 2018, 2018050455 (doi: 10.20944/preprints201805.0455.v1).

Abstract

Three new secoiridoid constituents Gonocarin A-C (1-3) and a new derivative Gonocarin A monoacetate (4), along with two known lignins pinoresinol (5) and paulownin (6) were isolated from the seed of Gonocaryum calleryanum (Baill.) Becc. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly mass spectroscopy and 2D NMR (1H–1H COSY, HMQC, HMBC, and NOESY) spectroscopy. When mouse macrophages RAW264.7 were treated with compounds 1-6 together with LPS -stimulated, a concentration-dependent inhibition of nitric oxide (NO) and tumor necrosis factor (TNF-α) productions were detected. The results confirmed that the Gonocaryum calleryanumrrg could be a potential anti-inflammatory agent.

Subject Areas

Gonocaryum calleryanum; secoiridoid; structure identification; anti-inflammatory.

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Rate this article
Views 0
Downloads 0
Comments 0
Metrics 0
Leave a public comment

×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.