Version 1
: Received: 18 May 2018 / Approved: 21 May 2018 / Online: 21 May 2018 (13:18:23 CEST)
How to cite:
Obbard, D.J. Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects. Preprints2018, 2018050278. https://doi.org/10.20944/preprints201805.0278.v1
Obbard, D.J. Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects. Preprints 2018, 2018050278. https://doi.org/10.20944/preprints201805.0278.v1
Obbard, D.J. Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects. Preprints2018, 2018050278. https://doi.org/10.20944/preprints201805.0278.v1
APA Style
Obbard, D.J. (2018). Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects. Preprints. https://doi.org/10.20944/preprints201805.0278.v1
Chicago/Turabian Style
Obbard, D.J. 2018 "Expansion of the Metazoan Virosphere: Progress, Pitfalls, and Prospects" Preprints. https://doi.org/10.20944/preprints201805.0278.v1
Abstract
Metagenomic sequencing has led to a recent and rapid expansion in the animal virome. It has uncovered a multitude of new virus lineages from under-sampled host lineages, including many that break up long branches among previously known clades, and many with genomes that display unexpected sizes and structures. Although there are challenges to inferring the existence of a virus from a virus-like sequence, the analysis of nucleic acid (including small RNAs) and sequence data can give us considerable confidence in the absence of an isolate. As a consequence, this period of ‘molecular natural history’ is helping to reshape our views of deep virus evolution. Nevertheless, there is a limit to what metagenomic discovery alone can tell us, and some open questions will require experimental isolates.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
