Preprint Review Version 3 This version is not peer-reviewed

Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System

Version 1 : Received: 18 April 2018 / Approved: 23 April 2018 / Online: 23 April 2018 (08:12:15 CEST)
Version 2 : Received: 3 May 2018 / Approved: 4 May 2018 / Online: 4 May 2018 (09:45:11 CEST)
Version 3 : Received: 12 May 2018 / Approved: 14 May 2018 / Online: 14 May 2018 (10:46:26 CEST)

How to cite: Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints 2018, 2018040275 (doi: 10.20944/preprints201804.0275.v3). Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints 2018, 2018040275 (doi: 10.20944/preprints201804.0275.v3).

Abstract

Antisocial behavior is a behavior disorder inherited according to the inheritance of X-linked chromosome. This disorder derives from mutations in the MAOA gene. One of the mutations results in the MAOA-L allele activity. The MAOA-L allele activity can cause antisocial behavior in both healthy and unhealthy people. Antisocial behavior from healthy males can originate from maltreatment during childhood. Currently, MAOA inhibitor can reverse antisocial behavior to normal behavior in animal models. However, this disorder cannot be treated permanently; to treat it permanently in the future, technologies such as CRISPR/Cas9, iPSCs and ssODN are required. These technologies have succeeded to correct erroneous segments in the F8 gene and F9 gene. Both genes occupy the X chromosome. The MAOA gene also occupies the X chromosome. Therefore, it is reasonable to state that CRISPR/Cas9 and iPSCs technique for instance can be beneficial tools to edit the MAOA gene to treat antisocial behavior. CRISPR/Cas9 can be used in combination with iPSCs or ssODN for instance. This combination can greatly help the permanent healing of antisocial behavioral disorders.

Subject Areas

advanced therapy; aggressive; antisocial; behavior; MAOA

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