Preprint Review Version 1 This version is not peer-reviewed

Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System

Version 1 : Received: 18 April 2018 / Approved: 23 April 2018 / Online: 23 April 2018 (08:12:15 CEST)
Version 2 : Received: 3 May 2018 / Approved: 4 May 2018 / Online: 4 May 2018 (09:45:11 CEST)
Version 3 : Received: 12 May 2018 / Approved: 14 May 2018 / Online: 14 May 2018 (10:46:26 CEST)

How to cite: Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints 2018, 2018040275 (doi: 10.20944/preprints201804.0275.v1). Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints 2018, 2018040275 (doi: 10.20944/preprints201804.0275.v1).

Abstract

Antisocial behavior is a behavior disorder inherited according to the inheritance of X-linked chromosome. Mutations in the MAOA gene can cause different behaviors in humans. These can comprise violent behavior or antisocial behavior. Low MAOA (MAOA-L) allele activity can cause antisocial behavior in both healthy and unhealthy people. Antisocial from healthy males can originate from maltreatment during childhood. There are no drugs for the treatment of antisocial behavior permanently at this time. MAOA inhibitor can reverse antisocial behavior in animal models. To cure antisocial behavior in the future, the CRISPR/Cas9 system in combination with iPSCs or ssODN methods for instance can be used. This system has succeeded to correct erroneous segments in the F8 gene and F9 gene. Both genes occupy the X chromosome. The MAOA gene also occupies the X chromosome. It seems that CRISPR/Cas9 system may be a beneficial tool to edit erroneous segments in the MAOA gene to treat antisocial behavior.

Subject Areas

advanced therapy, aggressive, antisocial, behavior, MAOA

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