Review
Version 2
Preserved in Portico This version is not peer-reviewed
Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System
Version 1
: Received: 18 April 2018 / Approved: 23 April 2018 / Online: 23 April 2018 (08:12:15 CEST)
Version 2 : Received: 3 May 2018 / Approved: 4 May 2018 / Online: 4 May 2018 (09:45:11 CEST)
Version 3 : Received: 12 May 2018 / Approved: 14 May 2018 / Online: 14 May 2018 (10:46:26 CEST)
Version 2 : Received: 3 May 2018 / Approved: 4 May 2018 / Online: 4 May 2018 (09:45:11 CEST)
Version 3 : Received: 12 May 2018 / Approved: 14 May 2018 / Online: 14 May 2018 (10:46:26 CEST)
How to cite: Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints.org 2018, 2018040275. https://doi.org/10.20944/preprints201804.0275.v2 Nelwan, M.L. Moderate the MAOA-L Allele Expression with CRISPR/Cas9 System. Preprints.org 2018, 2018040275. https://doi.org/10.20944/preprints201804.0275.v2
Abstract
Antisocial behavior is a behavior disorder inherited according to the inheritance of X-linked chromosome. This disorder derives from mutations in the MAOA gene. One of the mutations is the MAOA-L allele and result in MAOA-L activity. The MAOA-L allele activity can cause antisocial behavior in both healthy and unhealthy people. Antisocial behavior from healthy males can originate from maltreatment during childhood. Currently, MAOA inhibitor can reverse antisocial behavior to normal behavior in animal models. However, this disorder cannot be treated permanently; to treat it permanently in the future, technologies such as CRISPR/Cas9, iPSCs and ssODN are required. These technologies have succeeded to correct erroneous segments in the F8 gene and F9 gene. Both genes occupy the X chromosome. The MAOA gene also occupies the X chromosome. It is reasonable to state that CRISPR/Cas9 and iPSCs technique for instance can be beneficial tools to edit the MAOA gene to treat antisocial behavior. CRISPR/Cas9 can be used in combination with iPSCs or ssODN for instance. This combination can greatly help the permanent healing of antisocial behavioral disorders.
Keywords
advanced therapy; aggressive; antisocial; behavior; MAOA
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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