Preprint Article Version 1 This version is not peer-reviewed

Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

Version 1 : Received: 16 April 2018 / Approved: 17 April 2018 / Online: 17 April 2018 (08:52:17 CEST)
Version 2 : Received: 17 April 2018 / Approved: 18 April 2018 / Online: 18 April 2018 (08:23:58 CEST)

How to cite: Ahammad, I. Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach. Preprints 2018, 2018040219 (doi: 10.20944/preprints201804.0219.v1). Ahammad, I. Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach. Preprints 2018, 2018040219 (doi: 10.20944/preprints201804.0219.v1).

Abstract

Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology tools to identify the genes and proteins involved with them to get a better idea about the underlying molecular mechanisms including the regulatory mechanisms. Based on the analyses carried out, 7 significant modules have been identified from the PPI network. Five pathways/processes have been found to be significantly associated with DRS, HGPPS and CFEOM3 associated genes. From the PPI network, 3 have been identified as hub proteins- DRD2, UBC and CUL3.

Subject Areas

axon guidance; DRS; HGPPS; CFEOM3; in silico; systems biology; PPI network

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