Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations

Deepak Gupta; Deepak Bhatia; Vivek Dave; Vijaykumar Sutariya; Sheeba Varghese Gupta

doi:10.20944/preprints201804.0187.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 12 April 2018 / Approved: 16 April 2018 / Online: 16 April 2018 (05:29:24 CEST)

Choice of the salts of therapeutic agents or active pharmaceutical ingredients (API) is based on the physicochemical properties of API and the dosage form considerations. The appropriate salt can have positive effect on overall therapeutic and pharmaceutical effects of API. However, the incorrect salt form can negatively affect the overall pharmaceutical outcomes of the API. This review addresses various criteria for choosing appropriate salt form along with the effect of salt forms on API’s pharmaceutical properties. In addition to comprehensive review of the criteria, this review also gives a brief historic perspective of the salt selection process.

chemistry; salt; water solubility; routes of administration; physicochemical; stability; degradation

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Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations

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