Gupta, D.; Bhatia, D.; Dave, V.; Sutariya, V.; Varghese Gupta, S. Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations. Preprints2018, 2018040187. https://doi.org/10.20944/preprints201804.0187.v1
APA Style
Gupta, D., Bhatia, D., Dave, V., Sutariya, V., & Varghese Gupta, S. (2018). Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations. Preprints. https://doi.org/10.20944/preprints201804.0187.v1
Chicago/Turabian Style
Gupta, D., Vijaykumar Sutariya and Sheeba Varghese Gupta. 2018 "Salts of Therapeutic Agents: Chemical, Physicochemical and Biological Considerations" Preprints. https://doi.org/10.20944/preprints201804.0187.v1
Abstract
Choice of the salts of therapeutic agents or active pharmaceutical ingredients (API) is based on the physicochemical properties of API and the dosage form considerations. The appropriate salt can have positive effect on overall therapeutic and pharmaceutical effects of API. However, the incorrect salt form can negatively affect the overall pharmaceutical outcomes of the API. This review addresses various criteria for choosing appropriate salt form along with the effect of salt forms on API’s pharmaceutical properties. In addition to comprehensive review of the criteria, this review also gives a brief historic perspective of the salt selection process.
Keywords
chemistry; salt; water solubility; routes of administration; physicochemical; stability; degradation
Subject
Chemistry and Materials Science, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
