Preprint Review Version 1 This version is not peer-reviewed

The Initiation of Th2 Immunity towards Food Allergens

Version 1 : Received: 3 April 2018 / Approved: 4 April 2018 / Online: 4 April 2018 (07:35:35 CEST)

A peer-reviewed article of this Preprint also exists.

Ellenbogen, Y.; Jiménez-Saiz, R.; Spill, P.; Chu, D.K.; Waserman, S.; Jordana, M. The Initiation of Th2 Immunity Towards Food Allergens. Int. J. Mol. Sci. 2018, 19, 1447. Ellenbogen, Y.; Jiménez-Saiz, R.; Spill, P.; Chu, D.K.; Waserman, S.; Jordana, M. The Initiation of Th2 Immunity Towards Food Allergens. Int. J. Mol. Sci. 2018, 19, 1447.

Journal reference: Int. J. Mol. Sci. 2018, 19, 1447
DOI: 10.3390/ijms19051447

Abstract

In contrast to Th1 immune responses against pathogenic viruses and bacteria, the incipient events that generate Th2 responses remain less understood. Part of the difficulty in identifying universal operating principles stems from the diversity of entities against which cellular and molecular Th2 responses are produced. Indeed, such responses are launched towards harmful macroscopic parasites and noxious substances such as venoms but also against largely innocuous allergens. This suggests that the canonical understanding about sensing and recognition applied to Th1 responses may not be translatable to Th2 responses. This review will discuss processes and signals known to occur in Th2 responses, particularly in the context of food allergy. We propose that perturbations of homeostasis at barrier sites induced by external or internal subverters that either activate the immune system or lower its threshold activation are the major requirement for allergic sensitization. Innate signals produced in the tissue under these conditions equip dendritic cells with a program that shapes an adaptive Th2 response.

Subject Areas

Th2 immunity; food allergy; allergic sensitization; allergens; alarmins; initiation of allergy; IgE; allergic disease

Readers' Comments and Ratings (3)

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Comment 1
Received: 4 April 2018
Commenter: Karanbir Brar
The commenter has declared there is no conflict of interests.
Comment: This is a fantastic paper; really enjoyed the clear and straightforward writing style. Excellent work by Ellenbogen et. al.
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Comment 2
Received: 4 April 2018
The commenter has declared there is no conflict of interests.
Comment: Excellent summary of an important process in allergy and immunity.
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Comment 3
Received: 9 April 2018
The commenter has declared there is no conflict of interests.
Comment: Essential work in the field of allergy - a truly important read.
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