Preprint Article Version 1 This version is not peer-reviewed

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Version 1 : Received: 30 January 2018 / Approved: 31 January 2018 / Online: 31 January 2018 (05:28:15 CET)

How to cite: Simoben, C.V.; Ntie-Kang, F.; Akone, S.H.; Sippl, W. Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Preprints 2018, 2018010292 (doi: 10.20944/preprints201801.0292.v1). Simoben, C.V.; Ntie-Kang, F.; Akone, S.H.; Sippl, W. Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. Preprints 2018, 2018010292 (doi: 10.20944/preprints201801.0292.v1).

Abstract

Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species. Suggestions for future drug development from African medicinal plants have also been provided.

Subject Areas

African medicinal plants; Leishmaniasis; natural products; protozoal diseases; Schistosomiasis; Trypanosomiasis

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