Preprint Article Version 1 This version not peer reviewed

Influence of Chitosan Treatment in Obese Subjects on Surrogate Plasma Markers of Cholesterol Metabolism

Version 1 : Received: 5 January 2018 / Approved: 8 January 2018 / Online: 8 January 2018 (07:53:37 CET)
Version 2 : Received: 9 January 2018 / Approved: 10 January 2018 / Online: 10 January 2018 (10:51:03 CET)

A peer-reviewed article of this Preprint also exists.

Lütjohann, D.; Marinova, M.; Wolter, K.; Willinek, W.; Bitterlich, N.; Coenen, M.; Coch, C.; Stellaard, F. Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. Nutrients 2018, 10, 72. Lütjohann, D.; Marinova, M.; Wolter, K.; Willinek, W.; Bitterlich, N.; Coenen, M.; Coch, C.; Stellaard, F. Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. Nutrients 2018, 10, 72.

Journal reference: Nutrients 2018, 10, 72
DOI: 10.3390/nu10010072

Abstract

Chitosan treatment results in significantly lower plasma LDL-cholesterol concentrations. To test the working mechanism of Chitosan, we measured plasma surrogate markers of cholesterol absorption, synthesis, and degradation to bile acids corrected for cholesterol concentration (R_sterols). One hundred sixteen obese subjects (BMI 31.7, range 28.1 – 38.9 kg/m2) were studied under Chitosan treatment (n=61) and placebo treatment (n=55) during 12 weeks. The participants underwent a short nutrition education on how to improve quality of nutrition and energy expenditure. Daily Chitosan intake was 3200 mg. RESULTS. Plasma LDL-cholesterol concentration decreased significantly stronger (P=0.0252) under Chitosan (-8.67 ± 18.18 mg/dl, 5.6%) than under placebo treatment (-1.00 ± 24.22 mg/dl, 0.9%). This reduction was not associated with corresponding decreases of markers of cholesterol absorption under Chitosan treatment. As a marker for cholesterol synthesis R_lathosterol showed a trend towards a stronger decrease under Chitosan treatment (P=0.0759). Regarding markers of bile acid synthesis, R_7α-hydroxy-cholesterol decreased significantly only under Chitosan treatment, but not stronger than under placebo treatment. In conclusion, a significant selective reduction of plasma LDL-cholesterol under Chitosan treatment is neither associated with an expected reduction of plasma surrogate markers of cholesterol absorption nor with expected increases of markers for cholesterol and bile acid synthesis.

Subject Areas

cholesterol synthesis; bile acid synthesis; cholesterol absorption; lathosterol; plant sterols; oxysterols; lipoproteins; lipid lowering; phytosterols; placebo

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