Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

Marie-Cécile Alexandre-Gouabau
* ORCID logo ,
Thomas Moyon
,
Véronique Cariou
ORCID logo ,
Jean-Philippe Antignac
,
El Mostafa Qannari
,
Mikaël Croyal
,
Mohamed Molamine
,
Yann Guitton
ORCID logo ,
Agnès David-Sochard
,
Hélène Billard
,
Arnaud Legrand
,
Cécile Boscher
,
Dominique Darmaun
,
Jean-Christophe Rozé
,
Clair-Yves Boquien
ORCID logo
Version 1 : Received: 11 December 2017 / Approved: 11 December 2017 / Online: 11 December 2017 (15:53:33 CET)

A peer-reviewed article of this Preprint also exists.

Alexandre-Gouabau, M.-C.; Moyon, T.; Cariou, V.; Antignac, J.-P.; Qannari, E.M.; Croyal, M.; Soumah, M.; Guitton, Y.; David-Sochard, A.; Billard, H.; Legrand, A.; Boscher, C.; Darmaun, D.; Rozé, J.-C.; Boquien, C.-Y. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients 2018, 10, 164. Alexandre-Gouabau, M.-C.; Moyon, T.; Cariou, V.; Antignac, J.-P.; Qannari, E.M.; Croyal, M.; Soumah, M.; Guitton, Y.; David-Sochard, A.; Billard, H.; Legrand, A.; Boscher, C.; Darmaun, D.; Rozé, J.-C.; Boquien, C.-Y. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients 2018, 10, 164.

Abstract

Human milk is recommended for feeding preterm infant. Yet the potential impact of specific breast-milk lipid components on the initial growth rate of very-preterm infants has received scant attention. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth pattern of preterm infants fed their own mother’s milk. A prospective monocentric observational birth cohort was established, enrolling 147 preterm infants, who received their own mother’s breast-milk throughout hospital stay. Among that cohort, infants who experienced slow (n=15) or fast (n=11) growth were selected, based on the change in their weight Z-score between birth and hospital discharge (-1.54± 0.42 and -0.48± 0.19 Z-score, respectively). Liquid chromatography-high resolution-mass spectrometry was used to obtain lipidomic signatures in breast-milk. Multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between the 2 infants’ groups. Validation of the selected biomarkers was performed by means of various multidimensional statistical techniques, false-discovery rate and ROC curve computation. Breast-milk associated with fast growth contained more medium chain-saturated fatty acid and -sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. Their predictive ability of preterm early-growth rate was validated in presence of confounding clinical factors.

Keywords

breast milk lipidome, preterm infant, growth trajectory

Subject

Biology and Life Sciences, Food Science and Technology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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