Preprint Review Version 1 This version not peer reviewed

A Comprehensive Profile of Mature MicroRNA in the Pig

Version 1 : Received: 14 September 2017 / Approved: 14 September 2017 / Online: 14 September 2017 (10:09:19 CEST)
Version 2 : Received: 7 November 2017 / Approved: 7 November 2017 / Online: 7 November 2017 (10:53:19 CET)

How to cite: Wang, X.; Cooper, D.K.; Cai, Z.; Mou, L. A Comprehensive Profile of Mature MicroRNA in the Pig. Preprints 2017, 2017090057 (doi: 10.20944/preprints201709.0057.v1). Wang, X.; Cooper, D.K.; Cai, Z.; Mou, L. A Comprehensive Profile of Mature MicroRNA in the Pig. Preprints 2017, 2017090057 (doi: 10.20944/preprints201709.0057.v1).

Abstract

The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is non-coding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e.g., brain, lung, kidney, and liver). We also discuss the possible regulating mechanisms of miRNA. Finally, as pig organs are suitable candidates for xenotransplantation, biomarkers of their miRNA in xenotransplantation were evaluated.

Subject Areas

microRNA; pig; biomarker; xenotransplantation

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