Preprint Article Version 1 This version not peer reviewed

Chromosome pairing and recombination in male hybrids between two chromosome races of the common shrew (Sorex araneus L., Soricidae, Eulipotyphla)

Version 1 : Received: 1 September 2017 / Approved: 1 September 2017 / Online: 1 September 2017 (22:49:10 CEST)

How to cite: Belonogova, N.M.; Polyakov, A.V.; Karamysheva, T.V.; Torgasheva, A.A.; Searle, J.B.; Borodin, P. Chromosome pairing and recombination in male hybrids between two chromosome races of the common shrew (Sorex araneus L., Soricidae, Eulipotyphla). Preprints 2017, 2017090007 (doi: 10.20944/preprints201709.0007.v1). Belonogova, N.M.; Polyakov, A.V.; Karamysheva, T.V.; Torgasheva, A.A.; Searle, J.B.; Borodin, P. Chromosome pairing and recombination in male hybrids between two chromosome races of the common shrew (Sorex araneus L., Soricidae, Eulipotyphla). Preprints 2017, 2017090007 (doi: 10.20944/preprints201709.0007.v1).

Abstract

The hybrid zone between chromosome races of the common shrew (Sorex araneus) provides an exceptional model to study the potential role of chromosome rearrangements in the initial steps of speciation. The Novosibirsk and Tomsk races differ by a series of Robertsonian fusions with monobrachial homology. They form a narrow hybrid zone and generate hybrids with both simple (chain of three chromosomes) and complex (chain of eight or nine) synaptic configurations. Using immunolocalisation of the meiotic proteins, we examined chromosome pairing and recombination in males from the hybrid zone. Homozygotes and simple heterozygotes for Robertsonian fusions showed a low frequency of synaptic aberrations (< 10%). The carriers of complex synaptic configurations showed multiple pairing abnormalities, which might lead to reduced fertility. Recombination frequency in the proximal regions of most chromosomes of all karyotypes was much lower than in the other regions. The strong suppression of recombination in the pericentromeric regions and co-segregation of race specific chromosomes involved in the long chains would be expected to lead to linkage disequilibrium between genes located there. Genic differentiation, together with the high frequency of pairing aberrations in male carriers of the long chains, might contribute to maintenance of the narrow hybrid zone.

Subject Areas

common shrew; meiotic chromosomes; Sorex araneus; synaptonemal complex; hybrids; MLH1

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