Preprint Article Version 1 This version is not peer-reviewed

Maternal Supplementation with RRR-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

Version 1 : Received: 28 April 2017 / Approved: 2 May 2017 / Online: 2 May 2017 (17:20:34 CEST)

How to cite: Dametto, J.F.D.S.; Lira, L.Q.D.; Melo, L.R.M.; Damasceno, M.M.; Silva, N.L.D.N.; Dimenstein, R. Maternal Supplementation with RRR-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol. Preprints 2017, 2017050024 (doi: 10.20944/preprints201705.0024.v1). Dametto, J.F.D.S.; Lira, L.Q.D.; Melo, L.R.M.; Damasceno, M.M.; Silva, N.L.D.N.; Dimenstein, R. Maternal Supplementation with RRR-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol. Preprints 2017, 2017050024 (doi: 10.20944/preprints201705.0024.v1).

Abstract

Vitamin A and E are important during pregnancy, the neonatal period, and childhood. The objective of this study was to assess whether maternal RRR-a-tocopherol supplementation affects serum and breast milk retinol. Serum was collected at baseline and twenty days later, and breast milk, at baseline, and on days 1, 7, and 20 after delivery. After the baseline serum collection, the supplemented group (n=16) received a single 400 IU of RRR-α-tocopherol. The control group (n=18) was only performed collections. Retinol and alpha tocopherol levels were determined by liquid chromatography. Serum retinol and alpha tocopherol at baseline and 20 days after delivery indicated proper vitamin A (> 20 µg/dL) and E (> 516 μg/dL) statuses in the control and supplemented groups (p > 0.05). Colostrum retinol levels on days 1 and 7 after delivery were significantly higher in the supplemented group (p = 0.018 and p = 0.012, respectively). Maternal vitamin E supplementation increased colostrum retinol by 52.23% and 111.2%, 24 hours and 7 days, respectively. However, retinol in mature milk did not differ between the groups (p > 0.05). In conclusion, the supplementation with 400 IU of RRR-α-tocopherol improved vitamin A bioavailability in breast milk.

Subject Areas

Vitamin E; vitamin A; maternal serum; lactation; liquid chromatography.

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