Preprint Article Version 1 This version is not peer-reviewed

Cellular Morphology-Mediated Proliferation and Drug Sensitivity of Breast Cancer Cells

Version 1 : Received: 26 April 2017 / Approved: 26 April 2017 / Online: 26 April 2017 (17:38:07 CEST)

A peer-reviewed article of this Preprint also exists.

Domura, R.; Sasaki, R.; Ishikawa, Y.; Okamoto, M. Cellular Morphology-Mediated Proliferation and Drug Sensitivity of Breast Cancer Cells. J. Funct. Biomater. 2017, 8, 18. Domura, R.; Sasaki, R.; Ishikawa, Y.; Okamoto, M. Cellular Morphology-Mediated Proliferation and Drug Sensitivity of Breast Cancer Cells. J. Funct. Biomater. 2017, 8, 18.

Journal reference: J. Funct. Biomater. 2017, 8, 18
DOI: 10.3390/jfb8020018

Abstract

The interpretation of the local microenvironment of extracellular matrix for malignant tumor cells is in intimate relation with metastatic spread of cancer cells involving the associated issues of cellular proliferation and drug responsiveness. This study was aimed to assess the combination of both surface topographies (fiber alignments) and different stiffness of the polymeric substrates (PLLA and PCL) and collagen substrates (coat and gel) to elucidate the effect of the cellular morphology on cellular proliferation and drug sensitivities of two different types of breast cancer cells (MDA-MB-231 and MCF-7). The morphological spreading parameter of (Nuclear/Cytoplasm) induced by the anthropogenic substrates has correlated intimately with the cellular proliferation and the drug sensitivity (IC50) of cancer cells. This study demonstrated the promising results of the parameter for the evaluation of cancer cell malignancy.

Subject Areas

Spreading parameter; Cellular proliferation; Drug sensitivity; Substrates; Cancer cells

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