Preprint Article Version 1 This version is not peer-reviewed

Synthesis of Europium-doped Fluorapatite Nanorods and Their Multifunctional Biomedical Applications

Version 1 : Received: 5 April 2017 / Approved: 5 April 2017 / Online: 5 April 2017 (11:26:48 CEST)

A peer-reviewed article of this Preprint also exists.

Zeng, H.; Li, X.; Sun, M.; Wu, S.; Chen, H. Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery. Molecules 2017, 22, 753. Zeng, H.; Li, X.; Sun, M.; Wu, S.; Chen, H. Synthesis of Europium-Doped Fluorapatite Nanorods and Their Biomedical Applications in Drug Delivery. Molecules 2017, 22, 753.

Journal reference: Molecules 2017, 22, 753
DOI: 10.3390/molecules22050753

Abstract

Europium (Eu)-doped fluorapatite (FA) nanorods has a similar biocompatibility with hydroxyapatite (HA) in terms, attracted much attention as cell imaging biomaterials due to their luminescent property. Here, we will discuss the new feature of europium doped fluorapatite (Eu-FA) nanorods as anticancer drug carrier. Eu-FA nanorods was prepared using a hydrothermal method. The morphology, crystal structure, fluorescence and composition are investigated. The specific crystal structure, enabling an effective loading of drug molecules. Doxorubicin (DOX), used as an anticancer model drug, was shown to be effectively loaded onto the surface of the nanorods. The DOX release was fairly pH-dependent, occurring more rapidly at pH 5.5 than pH 7.4 was observed. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA show great promise for tracking and treating tumor, may potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs.

Subject Areas

lanthanides; fluorapatite; drug loading; nano carrier

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