Zebrafish as Toxicological Model for Screening and Recapitulate Human Diseases

Maria Virginia Caballero; Manila Candiracci

doi:10.20944/preprints201612.0103.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 20 December 2016 / Approved: 20 December 2016 / Online: 20 December 2016 (10:34:56 CET)

Embryonic and larval Danio rerio is increasingly used as a toxicological model to conduct rapid in vivo tests and developmental toxicity assays; the zebrafish features as high genetic homology to mammals; robust phenotypes; and its value in high-throughput genetic and chemical screening have made it a powerful tool to evaluate in vivo toxicity. New methodologies of genome editing as CRISPR/Cas9; ZFN or Talen make it a suitable model to perform studies to pair human genetic diseases as well. This review surveys recent studies; employing zebrafish as experimental model; comparing it with other in vivo and in vitro models; presenting zebrafish as a potent vertebrate tool to evaluate drug toxicity to facilitate more extensive; easy and comprehensive knowledge of new generation drugs.

zebrafish; models; evaluation; drugs; cardiotoxicity; genotoxicity

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Zebrafish as Toxicological Model for Screening and Recapitulate Human Diseases

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