Preprint Article Version 1 This version not peer reviewed

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Version 1 : Received: 27 August 2016 / Approved: 29 August 2016 / Online: 29 August 2016 (10:46:49 CEST)

A peer-reviewed article of this Preprint also exists.

Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146. Fan, D.; Zhu, G.-Y.; Li, T.; Jiang, Z.-H.; Bai, L.-P. Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii. Molecules 2016, 21, 1146.

Journal reference: Molecules 2016, 21, 1146
DOI: 10.3390/molecules21091146

Abstract

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Subject Areas

Tripterygium regelii; dimacrolide sesquiterpene pyridine alkaloids; anti-inflammation

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