Potential Application of Modified α-Mangostin Xanthones from Garcinia mangostana as Antibacterial Agents in Food Packaging

Srinivasan Narasimhan; Shanmugam Maheshwaran; Palmiro Poltronieri; Imad A. Abu-Yousef; Amin F. Majdalawieh; Janarthanam Rethavathi; Prince Edwin Das

doi:10.20944/preprints201608.0013.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 1 August 2016 / Approved: 2 August 2016 / Online: 2 August 2016 (09:02:09 CEST)

The microbial contamination in food packaging have been a major concern that paved the way for the search for natural based new anti-microbial agents, such as modified α-mangostin. In the present work, twelve synthetic analogs were obtained via semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher therapeutic value than the parent molecule. The anti-microbial studies proved that I E showed higher antibacterial activity whereas I I showed most significant antifungal activity. Due to their microbial properties, modified α-mangostin can be utilized as active anti-microbial agents in food packaging.

α-mangostin; antibacterial; antifungal; food packaging; semi-synthetic modification

CHEMISTRY, Medicinal Chemistry

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Potential Application of Modified α-Mangostin Xanthones from Garcinia mangostana as Antibacterial Agents in Food Packaging

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