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Preprint REVIEW | doi:10.20944/preprints202402.0137.v1

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Md Niaj. Morshed, Reshmi Akter, Imran Mahmud, Md. Rezaul Karim, Safia Iqbal, Md. jakaria Islam, Se Chan Kang, Deok Chun Yang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Ginsenoside compound K, Metabolic disease, obesity, NAFLD, Diabetes, osteoporosis

Online: 2 February 2024 (08:52:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1717.v1

Retrospective Review of Positive Newborn Screening Results for Isovaleric Acidemia and Development of a Strategy to Improve the Efficacy of Newborn Screening in the UK.

Rachel S Carling, Katy Hedgethorne, Anupam Chakrapani, Patricia L Hall, Nick Flynn, Toby Greenfield, Stuart J. Moat, Joshua Ssali, Lynette Shakespeare, Nazia Taj, Mark Anderson, Teresa H.Y. Wu, Arunabha Ghosh, Hugh Lemonde, Germaine Pierre, Mark Sharrard, Sreevidya Sreekantam, James R Bonham

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: isovaleric acidemia; false positive; newborn screening; inherited metabolic disease.

Online: 24 January 2024 (09:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0584.v1

Gait Variability at Different Walking Speeds

Johnny Padulo, Susanna Rampichini, Marta Borrelli, Daniel Maria Buono, Christian Doria, Fabio Esposito

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: human locomotion; symmetry; gait analysis; metabolic demand; kinematic analysis

Online: 10 October 2023 (10:34:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2173.v1

Efficacy of Postprandial Exercise in Mitigating Glycemic Responses in Individuals with Overweight, Obesity, and Type 2 Diabetes – A Systematic Review and Meta-Analysis

Jie Kang, Brian M Fardman, Nicholas A Ratamess, Avery D Faigenbaum, Jill A Bush

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Glycemic control, Hyperglycemia, Exercise protocols, Exercise timing, Metabolic disorders

Online: 2 October 2023 (11:25:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2034.v1

The Supplementation of Sechium edule var. Nigrum Spinosum (Chayote) Promotes Nrf2-Mediated Antioxidant Protection in Older Adults with Metabolic Syndrome

Graciela Gavia-García, David Hernández-Álvarez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez

Subject: Biology And Life Sciences, Aging Keywords: Sechium edule; metabolic syndrome; antioxidants; markers inflammatory; aging; RNAm

Online: 30 August 2023 (05:16:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1245.v1

Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease

Jaehyun Bae, Byung-Wan Lee

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetic kidney disease; metabolic-associated fatty liver disease; biomarker

Online: 16 June 2023 (13:36:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2022.v1

Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children

Giovanna Scorrano, Saverio La Bella, Sara Matricardi, Francesco Chiarelli, Cosimo Giannini

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic syndrome; obesity; neuroendocrine systems; stress response; genetic polymorphisms

Online: 30 May 2023 (02:27:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0020.v1

Multiple Pesticide Resistance in Rust-Red Fluor Beetle (Tribolium castaneum, Herbst 1797) from Northern Nigeria is Probably Driven by Metabolic Mechanisms

Muhammad M. Mukhtar, Muhammad A. Mustapha, Mubarak Aliyu, Sulaiman S. Ibrahim

Subject: Biology And Life Sciences, Insect Science Keywords: red flour beetle; Tribolium castaneum; pesticides; insecticides; resistance, metabolic

Online: 2 February 2023 (01:57:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0198.v1

Mechanisms and Outcomes of Metabolic Surgery in Type 2 Diabetes

Mansor Fazliana, Zubaidah Nor Hanipah

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes; bariatric surgery; metabolic surgery; hormones; adipokines; microRNA; metabolomic

Online: 14 October 2022 (03:12:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0202.v1

SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

Clayton Goddard, Karin Allenspach, Audrey Deflandre, Claudine Zemirline, Emilie Guillot, Jonathan P. Mochel

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic syndrome; SGLT2 inhibitors; Dapagliflozin; Empagliflozin; Canagliflozin; Translational modeling

Online: 21 April 2022 (10:12:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0463.v1

Examine the Association between Metabolic Syndrome and Frailty in an Older Asian Population

Hiep Huu Hoang Dao, Anh Trung Nguyen, Huyen Thi Thanh Vu, Tu Ngoc Nguyen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: metabolic syndrome; diabetes; hypertension; obesity; frailty; older people; Asian

Online: 29 December 2021 (12:09:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0188.v1

Modifiable Lifestyle Factors and their Relationships with Metabolic Disorders among Adults in Burkina Faso: Findings from the First National Survey

Jeoffray Diendéré, Jean Kaboré, Augustin Nawidimbasba Zeba, William Kofi Bosu, Jérôme Winbetourefa Somé, Franck Garanet, Victor Pingdéwendé Ouédraogo, Abdoul Aziz Savadogo, Athanase Millogo

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Modifiable lifestyle factors; Metabolic disorders; Prevalence; Relationships; Burkina Faso

Online: 12 October 2021 (21:02:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0637.v1

The Association Between Vitamin C Deficiency and Metabolic Syndrome Among Patients Who Developed Kidney Disease

Ayenew Negesse, Beminet Moges, Tigest kebede, Abiy Kifle, Dagim Alemayehu, Yilkal Negesse, Sisay Tesfaye, Alemu Fite

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Metabolic syndrome; vitamin C deficiency; kidney disease; Albuminuria; USA

Online: 26 May 2021 (13:10:40 CEST)

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Introduction: Elevated albuminuria is an important outcome of diabetic complications and metabolic syndrome (MetS), the complex metabolic abnormalities manifested as glucose intolerance, hypertension, and dyslipidemia and enlarged waist circumference. These coexisting cardio-metabolic abnormalities are also associated with oxidative stress and low grade inflammation. Vitamin C (vitC) has long been recognized as hydrophilic antioxidant and blocker of oxidative stress which also has a protective role of MetS and kidney disease. Objective: The aim of this study was to identify the predictive effect of vitC deficiency on kidney disease among patients who developed metabolic syndrome. Method and procedures: To meet this objective, the National Health and Nutrition Examination Survey (NHANES) 2007-2008 data were used. NHANES represents the civilian, non-institutionalized US population data implemented for continuous system of monitoring health, nutritional status and well-being in the US. The predictive power of MetS on AU and vitC deficiency (vitC < 0.25 mg/dl) as effect modifier was assessed with binary logistic regression. Age, gender, race and BMI were used as covariates. Results: Among the respondents, 1.9% of the US population had risk of kidney damage, whereas 14.5 % of respondents had MetS. MetS was significantly positively correlated with AU (p < 0.01). Higher elevation of albuminuria creatinine ratio (ACR) was found in participants with VCD. The regression models developed in this study showed that the severity of kidney disease measured by ACR was increased among individuals who developed both VCD and MetS compared with individuals who developed MetS only (AOR=5.53; 95% CI: 2.73, 11.21). Increasing age and being African-American in race were independently associated with elevated AU. Conclusion: Specific considerations tailored to metabolic syndrome, vitamin C and kidney diseases measured by ACR screening and monitoring mechanisms at the community level is critical to tackle further medical complications. Moreover, the role of VitC fortified foods on prevention of kidney diseases among patients with MetS warrant further investigation.

Preprint ARTICLE | doi:10.20944/preprints202103.0023.v1

Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated with Maternal Undernutrition

Polyxeni-Maria Sarli, Antigoni Manousopoulou, Elias Efthymiou, Andreas Zouridis, Anastasios Potiris, Panagiota Pervanidou, Konstantinos Panoulis, Nikolaos Vlahos, Efthimios K. Deligeoroglou, Spiros D. Garbis, Makarios Eleftheriades

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: FGR; fetal programming; food restriction; metabolic disorders; liver proteomics

Online: 1 March 2021 (13:54:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0517.v1

Metabolite Transporter and Its Impact on Metabolic Engineering Approaches

Mostafa Gomaa FADL

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gram-negative bacterial; Metabolite transporter; pathways; metabolic engineering approaches

Online: 25 January 2021 (15:49:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0516.v1

From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) – New Terminology in Pediatric Patients as a Step in Good Scientific Direction?

Marta Flisiak-Jackiewicz, Anna Bobrus-Chociej, Natalia Wasilewska, Dariusz Lebensztejn

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: MAFLD; NAFLD; fatty liver; metabolic syndrome; obesity; children; nomenclature

Online: 25 January 2021 (15:36:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0399.v1

The Association between Vitamin C Deficiency and Metabolic Syndrome among Patients who Developed Kidney Disease

Ayenew Negesse, Beminet Moges, Tigest Kebede, Abiy Kifle, Dagim Alemayehu, Yilkal Negesse, Sisay Tesfaye, Alemu Fite

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: metabolic syndrome; vitamin C deficiency; kidney disease; Albuminuria; USA

Online: 16 December 2020 (09:43:21 CET)

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Introduction: Elevated albuminuria is an important outcome of diabetic complications and metabolic syndrome (MetS), the complex metabolic abnormalities manifested as glucose intolerance, hypertension, and dyslipidemia and enlarged waist circumference. These coexisting cardio-metabolic abnormalities are also associated with oxidative stress and low grade inflammation. Vitamin C (vitC) has long been recognized as hydrophilic antioxidant and blocker of oxidative stress which also has a protective role of MetS and kidney disease. Objective: The aim of this study was to identify the predictive effect of vitC deficiency on kidney disease among patients who developed metabolic syndrome. Method and procedures: To meet this objective, the National Health and Nutrition Examination Survey (NHANES) 2007-2008 data were used. NHANES represents the civilian, non-institutionalized US population data implemented for continuous system of monitoring health, nutritional status and well-being in the US. The predictive power of MetS on AU and vitC deficiency (vitC < 0.25 mg/dl) as effect modifier was assessed with binary logistic regression. Age, gender, race and BMI were used as covariates. Results: Among the respondents, 1.9% of the US population had risk of kidney damage, whereas 14.5 % of respondents had MetS. MetS was significantly positively correlated with AU (p < 0.01). Higher elevation of albuminuria creatinine ratio (ACR) was found in participants with VCD. The regression models developed in this study showed that the severity of kidney disease measured by ACR was increased among individuals who developed both VCD and MetS compared with individuals who developed MetS only (AOR=5.53; 95% CI: 2.73, 11.21). Increasing age and being African-American in race were independently associated with elevated AU. Conclusion: Specific considerations tailored to metabolic syndrome, vitamin C and kidney diseases measured by ACR screening and monitoring mechanisms at the community level is critical to tackle further medical complications. Moreover, the role of VitC fortified foods on prevention of kidney diseases among patients with MetS warrant further investigation.

Preprint ARTICLE | doi:10.20944/preprints202006.0283.v1

Increased Aldehyde Formation as a Key Component of the Metabolic Syndrome in Adolescents: A Machine Learning Study

Kamila Bonifacio, Michael Maes, Carine de Farias, Andressa Matsumoto, Crisieli Tomereli, Danilo Pereira da Silva, Edilson Cyrino, Suzana Nixdorf, Danielle Venturini, Decio Barbosa

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Metabolic Syndrome; Obesity; inflammation; Oxidative Stress; nitrosative stress; biomarkers

Online: 23 June 2020 (11:35:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0496.v1

Exploring the Potential of β-Catenin O-GlcNAcylation by Using Fluorescence-Based Engineering and Imaging

Angelina Kasprowicz, Corentin Spriet, Christine Terryn, Matthew G. Alteen, Tony Lefebvre, Christophe Biot

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: bioorthogonal chemistry; fluorescence; glycosylation; metabolic incorporation; GFP; beta-catenin

Online: 31 May 2020 (19:37:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0015.v1

Beneficial Effects of Multicomponent Functional Foods in Patients with Metabolic Syndrome

Simona Dragan, Georgiana Damian, Dana Velimirovici, Maria Rada, Delia Berceanu, Mircea Iurciuc, Marius Badalica-Petrescu, Mihaela Valcovici, Carmen Socaciu, Ruxandra Christodorescu

Subject: Biology And Life Sciences, Food Science And Technology Keywords: metabolic syndrome; multicomponent functional foods; antioxidant bioactive ingredients; polyphenols

Online: 2 November 2018 (05:06:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0274.v1

Comparative Rice Bran Metabolomics across Diverse Cultivars and Functional Rice Gene-Bran Metabolite Relationships

Iman Zarei, Emily Luna, Jan E. Leach, Anna McClung, Samuel Vilchez, Ousmane Koita, Elizabeth P. Ryan

Subject: Chemistry And Materials Science, Food Chemistry Keywords: rice bran; rice genes; rice cultivars; metabolic pathway; metabolomics

Online: 15 September 2018 (19:34:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0210.v1

Intestinal Microbial and Metabolite Profiling of Mice Fed with Dietary Glucose and Fructose

João C. P. Silva, Marta Mota, Fátima O. Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S. Barros, John G. Jones, Ana M. Gil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: fructose; intestinal microbiota; short-chain fatty acids; metabolic profiling

Online: 23 January 2018 (05:31:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1550.v1

Bacterial Diversity, Metabolic Profiling and Application Potential of Antarctic Soil Metagenomes

Mario Fernandez, Salvador Barahona, Fernando Gutiérrez, Jennifer Alcaíno, Víctor Cifuentes, and Marcelo Baeza

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: shot-gun metagenomes; Antarctica; bacterial diversity; metabolic profiling; applied enzymes

Online: 19 July 2024 (10:37:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1490.v1

Metabolic Engineering in Plants: Enhancing Crop Yield and Quality

Katie Fan

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Metabolic engineering; crop improvement; stress tolerance; synthetic biology; CRISPR/Cas9

Online: 18 July 2024 (10:54:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.1789.v1

GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells

Juan De los Santos-Jiménez, José A. Campos-Sandoval, Francisco J Alonso, Javier Márquez, José M Matés

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cancer; ferroptosis; glutaminase; glutaminolysis; glutathione; metabolic reprogramming; oxidative stress; ROS

Online: 27 May 2024 (15:48:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1500.v1

Identification of Anastatica hierochuntica L. Methanolic Leaves Extract-Derived Metabolites Exhibiting Xanthine Oxidase Inhibitory Activities: In Vitro and in Silico Approaches

Saranya Rameshbabu, Zeyad Alehaideb, Sahar S Alghamdi, Rasha S Suliman, Feras Almourfi, Syed Ali Mohamed Yacoob, Anuradha Venkataraman, Safia Messaoudi, Sabine Matou-Nasri

Subject: Biology And Life Sciences, Life Sciences Keywords: Anastatica hierochuntica; chemical composition; metabolites; metabolic enzyme inhibitor; xanthine oxidase

Online: 23 May 2024 (10:53:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1170.v1

Relationship of Mediterranean Diet with Metabolic Syndrome and Its Components in Caucasian Subjects: A Cross-Sectional trial

Leticia Gómez-Sánchez, Marta Gómez-Sánchez, Olaya Tamayo-Morales, Cristina Lugones-Sanchez, Susana González-Sánchez, Ruth Martí-Lluch, Emiliano Rodriguez-Sanchez, Luis Garcia-Ortiz, Manuel Angel Gomez-Marcos

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Mediterranean diet; metabolic syndrome; Caucasian subjects; A cross-sectional trial

Online: 17 May 2024 (15:31:33 CEST)

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The primary aim of this study is to investigate the relationship of the Mediterranean diet (MD) with metabolic syndrome (MetS) and its components in Caucasian subjects between 35 and 74 years. The secondary aim is to analyze sex differences. Methods: A cross‑sectional trial. This study utilized data from the EVA, MARK, and EVIDENT studies, a total of 3417 subjects with a mean age of 60.14±9.14 years (57% men). MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured. Adherence to the MD was assessed with the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire used in the PREDIMED study. Good adherence was considered when the MD value was higher than the median value. Results: The mean value of the MEDAS questionnaire was 5.83±2.04; (Men 5.66±2.06 and women 6.04±1.99; p<0.001). Adherence to the MD was observed by 38.6% (34.3% men and 40.3% women; p<0.001). MetS was observed in 41.6% (39.0% men and 45.2%women p<0.001). In the multiple regression analysis after adjusting for possible confounders, the mean MD value showed a negative association with the number of MetS components per subject (β=-0.336), and with the different components of MetS: Systolic blood pressure (β=-0.011), Diastolic blood pressure (β=-0.029), glycemia (β=-0.009), Triglycerides (β=-0.004), Waist circumference (β=-0.026), except with the HDL-cholesterol value which showed a positive association (β=0.021); (p<0.001 in all cases). The adjusted logistic regression models showed that an increase in MDA decreases the probability of MetS (OR =0.56) and its components: blood pressure ≥130/85 mmHg (OR = 0.63), fasting plasma glucose ≥100 mg/dL (OR = 0.62); triglycerides ≥150 mg/dL (OR = 0.65); waist circumference ≥88 cm in women and ≥102 cm in men (OR = 0.74), and increases high-density lipoprotein cholesterol <40 mg/dL in men or <50 mg/dL in women (OR = 1.70); (p<0.001 in all cases). The results by sex were similar, both in multiple regression and logistic regression. Conclusion: The results of this study suggest that a greater adherence to the Mediterranean diet decreases the probability of presenting Mets globally and by sex.

Preprint ARTICLE | doi:10.20944/preprints202402.1157.v1

Melatonin Improves Glucose Homeostasis and Insulin Sensitivity by Mitigating Inflammation and Activating AMPK Signaling in a Mouse Model of Sleep Fragmentation

Seok Hyun Hong, Da-Been Lee, Jinkwan Kim, Dae-Wui Yoon

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: sleep fragmentation; metabolic dysfunction; AMP-activated protein kinase (AMPK); melatonin

Online: 20 February 2024 (15:20:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0720.v2

Mitochondrial Respiration and Morphological Alterations in Different Adipose Tissues in Rats Treated with a High-Fat Diet and a Single Low-Dose Streptozotocin Injection or a Fructose Solution

Evgenii Ivanov, Marina Akhmetshina, Aleksei Erdiakov, Albina Gizatulina, Svetlana Gavrilova

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes mellitus; metabolic syndrome; obesity; adipose tissue; mitochondrial respiration; OXPHOS

Online: 14 December 2023 (10:54:12 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0468.v2

Successfully Managed Alcoholic Ketoacidosis With Sepsis Leading to Mods: A Case Report

Ishita Roy, Nilanjan Roy

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: alcoholic ketoacidosis; sepsis; multiple organ dysfunction syndrome; thiamine; metabolic acidosis

Online: 13 December 2023 (03:15:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2052.v1

Comparative Metabolomic and Network Analysis of the Hyperaccumulation of Astaxanthin in Haematococcus pluvialis under the Different Stress Conditions

Yong Dou, Jiayi Li, Zhiyi Qiao, Wenli Zhou

Subject: Biology And Life Sciences, Aquatic Science Keywords: Haematococcus pluvialis; Astaxanthin; Environmental stress factors; Metabolomic analysis; Metabolic network

Online: 31 October 2023 (10:20:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1991.v1

Scoping Review of Clinical Evidence for the Health Benefits of Culinary Doses of Herbs and Spices for Prevention and Treatment of Metabolic Syndrome

Marion Mackonochie, Ana Rodriguez-Mateos, Simon Mills, Vivien Rolfe

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: diabetes; herbs and spices; metabolic syndrome; nutrition; phytochemicals; preventative health

Online: 31 October 2023 (04:09:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1117.v1

Perspectives for Using CO2 as a Feedstock for Biomanufacturing

Elif Kurt, Jiansong Qin, Alexandria R Williams, Youbo Zhao, Dongming Xie

Subject: Engineering, Bioengineering Keywords: Metabolic engineering; CO2 fixation; feedstock; biomanufacturing; electrochemical catalysis; microbial electrosynthesis

Online: 18 October 2023 (08:17:15 CEST)

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Microbial cell factories offer an eco-friendly alternative for transforming raw materials into commercially valuable products, primarily because of their reduced carbon impact compared to conventional industrial procedures. These systems often depend on lignocellulosic materials, mainly pentose and hexose sugars, richly available carbon reservoirs. Nevertheless, these resources might not always be efficient due to the limited supply, significant cost, and other considerable obstacles. One major hurdle when working with sugars derived from lignocellulosic biomass, especially glucose, is balancing carbon allocation to satisfy energy, cofactor, and other essential component needs for cellular proliferation while maintaining a robust yield. Furthermore, nearly half or more of this carbon is inevitably lost as CO2 during the biosynthesis processes, which serves to generate the energy necessary for maintaining cell growth and other regular metabolic activities. This carbon loss lowers the theoretical production yield and compromises the benefit of reducing greenhouse gas emissions – a fundamental advantage of biomanufacturing. This review paper posits the perspectives of using CO2 from atmosphere, industrial wastes, or the exhausted gases generated in microbial fermentation as a feedstock for biomanufacturing. Both one-step direct CO2 fixation or two-step indirect CO2 fixation and conversion strategies are discussed, which can minimize the carbon loss, significantly increase the carbon yield, and eventually achieve the carbon-neutral or -negative goals. The one-step strategy uses novel metabolic pathway design and engineering approaches to directly fix the CO2 via the pathway toward the synthesis of the desired fermentation products. Due to the limitation of the yield and efficiency in one-step CO2 fixation, the two-step strategy aims to completely avoid carbon loss in biomanufacturing by integrating a first electrochemical fixation of the exhausted CO2 into C1/C2 products such as formate, methanol, acetate, and ethanol and a second fermentation unit to utilize the CO2-derived C1/C2 chemicals or co-utilize both C5/C6 sugars and C1/C2 chemicals for product formation. The great potentials and challenges of using CO2 as a feedstock for further biomanufacturing are also discussed.

Preprint ARTICLE | doi:10.20944/preprints202310.0604.v1

Bone Microarchitecture Alterations Are Associated With the TP53 Arg72Pro Polymorphism

Ricardo Usategui-Martín, Nadia Galindo-Cabello, Salvador Pastor-Idoate, José María Fernandez-Gómez, Alvaro del Real, Diego Ferreño, Rebeca Lapresa, Francisco Martín-Rodriguez, José A Riacho, Angeles Almeida, Jose-Luis Pérez-Castrillón

Subject: Medicine And Pharmacology, Internal Medicine Keywords: metabolic bone diseases; osteoporosis; TP53; p53; apoptosis and gene polymorphism

Online: 10 October 2023 (10:41:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1864.v1

Plant-Wide Target Metabolomics Provides A Novel Interpretation of the Changes in Chemical Ingredients during Dendrobium officinale Traditional Processing

Pengfei Liu, Bei Fan, Yuwen Mu, Litao Tong, Cong Lu, Long Li, Jiameng Liu, Jing Sun, Fengzhong Wang

Subject: Chemistry And Materials Science, Food Chemistry Keywords: Dendrobium officinale; traditional processing; widely-targeted metabolic analysis; chemical ingredients

Online: 27 September 2023 (10:54:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2032.v1

Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism

Ahmed S. S BaHammam, Rouf Pirzada

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: dawn; melatonin; clock genes; metabolic health; glucose control; dinner; cortisol

Online: 28 June 2023 (12:36:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0461.v1

Increased Adipocyte Hypertrophy in Patients with Nascent Metabolic Syndrome

Ishwarlal Jialal, Beverley Huet, Sridevi Deveraj

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Fat cell size; gluteal fat; inflammation; fibrosis; angiogenesis; metabolic syndrome

Online: 6 June 2023 (12:58:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0190.v1

Exploring New Tools to Risk Classification Among Adults with Several Degrees of Obesity

Greice Westphal-Nardo, Jean-Philippe Chaput, César Faúndez-Casanova, Carlos Alexandre Molena Fernandes, Eliane Cristina de Andrade Gonçalves, Raquel Tomiazzi Utrila, Karine Oltramari, Felipe Merchan Ferraz Grizzo, Nelson Nardo-Junior

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: obesity; risk assessment; metabolic syndrome; AIP; HOMA-IR; risk stratification

Online: 4 May 2023 (04:32:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0315.v1

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana: A Mini-Review

Md. Ahsan Habib, Md. Mobinul Islam, Md. Mukul Islam, Md. Mohidul Hasan, Kwang-Hyun Baek

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Nicotiana; alkaloids; anti-tumor; metabolic engineering; de-novo synthesis ;

Online: 13 April 2023 (08:53:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0002.v1

Lipid Metabolism Reprogramming Is Associated with Trastuzumab Resistance in ERBB2+ Breast Cancer Cell Lines

Katia Cortese, Marco Ponassi, Aldo Profumo, Gabriela Coronel Vargas, Erika Iervasi, Maria Cristina Gagliani, Grazia Bellese, Sara Tavella, Patrizio Castagnola

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: trastuzumab; trastuzumab resistance; HER2; breast cancer; proteomic analysis; metabolic reprogramming.

Online: 3 April 2023 (02:19:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0004.v1

Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease

Satu Pekkala

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: gut microbiota; metabolomics; metagenomics; liver fat; NAFLD; diet; metabolic pathways

Online: 1 March 2023 (02:40:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0467.v1

Genetic Diversity of Cytochrome P450s CYP6M2 and CYP6P4 Associated with Pyrethroid Resistance in the Major Malaria Vectors Anopheles coluzzii and Anopheles gambiae from Yaoundé, Cameroon

Yvan Gaetan Fotso-Toguem, Billy Tene-Fossog, Leon M.J. Mugenzi, Murielle J. Wondji, Flobert Njiokou, Hilary Ranson, Charles S. Wondji

Subject: Biology And Life Sciences, Insect Science Keywords: CYP6M2; CYP6P4; polymorphism; metabolic resistance; pyrethroid; Anopheles coluzzii; Anopheles gambiae

Online: 25 November 2022 (05:51:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0026.v1

Tracking Obesity Phenotypes in Korean Adults Based on KNHANES (2015-2019)

Jieun Shin, Okhyun Kim, Myoungsook Lee

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: obesity phenotypes, obesogenic environments, metabolic syndrome, K-score, food pattern

Online: 1 November 2022 (09:36:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0239.v1

Bioengineering of Escherichia coli Nissle 1917 for Overproduction and Excretion of Spermidine, a Key Metabolite in Human Health

Clement Caffaratti, Caroline Plazy, Valérie Cunin, Bertrand Toussaint, Audrey Le Gouellec

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Microbiota; Immunity; Spermidine; Metabolic engineering; Probiotics; Live Biotherapeutic Product; Metabolomics

Online: 17 October 2022 (12:09:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0355.v1

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates

Surbhi Jain, Utkarsha Sahu, Awanish Kumar, Prashant Khare

Subject: Biology And Life Sciences, Parasitology Keywords: Leishmania; Human Pathogen; Targeting Metabolic Pathways; Repurposed Drugs; New Antileishmanials.

Online: 27 June 2022 (08:47:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0071.v1

Macronutrient Intake in Adults Diagnosed with Metabolic Syndrome: using the Health Examinee (HEXA) Cohort

Hyerim Park, Anthony Kityo, Yeon-Jin Kim, Sang-Ah Lee

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Macronutrient intake; Metabolic syndrome; the Korean Health Examinee (HEXA) stud

Online: 3 November 2021 (09:07:55 CET)

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Working Paper ARTICLE

Associations between Dietary Pattern, Bioactive Algal Nutrients Supplementation and Metabolic Risk Markers in Japanese Women: The NAMI Pilot Study

Ngatu Roger Nlandu, Tomohiro Hirao, Mitsunori Ikeda

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Adiponectin; Adiponectin modulation inducer; C-reactive protein; Metabolic marker; Sujiaonori.

Online: 20 July 2021 (14:46:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0415.v1

Associations between Bioactive Algal Biomaterial Supplementation, Dietary Pattern and Metabolic Risk Markers in Japanese Women

Nlandu Roger Ngatu, Tomohiro Hirao, Mitsunori Ikeda

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Adiponectin; Adiponectin modulation inducer; C-reactive protein; Metabolic marker; Sujiaonori.

Online: 19 July 2021 (14:28:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0202.v1

The Metabolic Bone Disease X-Linked Hypophosphatemia: Case Presentation, Pathophysiology and Pharmacology

Jon Vincze, Brian W Skinner, Katherine A Tucker, Jonathan W Lowery, Julia M Hum

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: metabolic bone disease; burosumab; KRN23; x-linked hypophosphatemia; crysvita; xlh

Online: 10 May 2021 (14:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0209.v1

Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach

Snehal R. Jadhav, Rohan M. Shah, Avinash V. Karpe, Robert Barlow, Kate McMillan, Michelle L. Colgrave, David J. Beale

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: leafy greens; spinach; metabolomics; metabolic profiling; food pathogens; biomarker discovery

Online: 12 January 2021 (08:20:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0338.v1

Treatment Strategies and Metabolic Pathway Regulation in Urothelial Cell Carcinoma: A Comprehensive Review

Huang-Yu Yang, Chao-Yi Wu, Jia-Jin Chen, Tao-Ha Lee

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Urothelial carcinoma; immune checkpoint inhibitors; immunotherapy; tumor microenvironment; metabolic pathway

Online: 16 October 2020 (08:00:41 CEST)

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Working Paper REVIEW

Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19

Ersilia Nigro, Rita Polito, Andreina Alfieri, Annamaria Mancini, Esther Imperlini, Ausilia Elce, Peter Krustrup, Stefania Orrù, Pasqualina Buono, Aurora Daniele

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Physical Activity; COVID-19; healthy lifestyle; metabolic disorders; immune system

Online: 7 June 2020 (11:31:17 CEST)

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Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201610.0132.v1

Geography of Food Consumption Patterns between South and North China

Fangfang Song, Mi Sook Cho

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chinese adults; north region; south region; dietary pattern; metabolic syndrome

Online: 31 October 2016 (02:51:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202410.2224.v1

Metabolic Syndrome: Current State and Prospects

Wei-Zheng Zhang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: ; Caveolae; Metabolic diseases; Lifestyle alteration; Personalized medicine ;

Online: 29 October 2024 (08:49:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1980.v1

Enhanced Outer Membrane Vesicle Production in Escherichia coli: from Metabolic Network Model to Designed Strain Lipidomic Profile

Héctor Alejandro Ruiz-Moreno, Juan Daniel Valderrama-Rincon, Monica Patricia Cala, Miguel Fernández-Niño, Andrés Fernando Gonzalez Barrios

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Outer Membrane Vesicles; Lipidomics; CRISPR; Metabolic Network Models; E. coli JC8031

Online: 25 September 2024 (12:15:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1728.v1

Microencapsulated Pomegranate Juice Reduces Metabolic Syndrome (MetS) Criteria in Wistar Rats With MetS Induced With 30% Sucrose

José Antonio Guerrero-Solano, Juan Carlos Cancino-Díaz, Osmar Antonio Jaramillo-Morales, Mirandeli Bautista, Juan Pablo Hernández-Uribe, José Moisés Talamantes-Gómez, Carmen Valadez-Vega, Helen Belefant-Miller, Gabriel Betanzos-Cabrera

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Metabolic syndrome; Microencapsulated pomegranate juice; Cardiovascular diseases; Punica granatum; Biochemical markers

Online: 23 September 2024 (13:11:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1123.v1

Transcriptomic Profiling Reveals Altered Expression of Genes Involved in Metabolic and Immune Processes in NDV-Infected Chicken Embryos

Malarmathi Muthusamy, Kannaki T Ramasamy, Sunday Olusola Peters, Srinivasan Palani, Gowthaman Vasudevan, Murali Nagarajan, Sivakumar .Karuppusamy, Vasanthakumar Thangavelu, Thiruvenkadan Aranganoor kannan

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: NDV; Chicken; Aseel; Kadaknath; White leghorn; Immune gene; Metabolic genes; HSP

Online: 15 September 2024 (07:32:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0980.v1

Does the Metabolic Syndrome and Its Components Have Prognostic Significance for Renal and Cardiovascular Outcomes in IgA Nephropathy?

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; IgA nephropathy; Renal function; Metabolic syndrome; Arterial stiffness

Online: 15 April 2024 (14:53:42 CEST)

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Background: Cardiovascular (CV) morbidity and mortality are many times higher in chronic kidney disease (CKD), as well as IgA nephropathy (IgAN), than in the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The study aimed to determine the prognostic role of metabolic profiles in a homogenous group of CKD patients. Methods: One hundred and forty-five IgA nephropathy patients (92 male, 53 female, age 54.7 ± 13 years) with CKD stage 1-4 were investigated and followed for a median of 190 months. The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularization (CV), end-stage renal disease, and renal replacement therapy (renal). Results: Patients with MetS had significantly more endpoint events (16/27 patients vs. 15/98 patients, p = 0.001) compared to the nonMetS group. Of the secondary endpoints (CV or renal separately), the rate of the renal and CV endpoints was significantly higher in the MetS group (p = 0.001 and p = 0.029). The primary endpoint independent predictors of survival were dyslipidemia, eGFR, hemoglobin, urine albuminuria, and diabetes mellitus, as determined by Cox regression analysis. Independent predictors of secondary renal endpoint were dyslipidemia, hemoglobin, urine albumin, and eGFR. Predictors of secondary cardiovascular endpoints were gender, BMI, and diabetes. Kaplan-Meier curves showed significant differences in MetS and non-MetS when examined at the combined endpoints (CV and renal) or at each endpoint separately. The primary endpoint rate increased significantly with the increased number of MetS components (MetS comp. 0 vs. MetS comp. 2+, primary endpoints, p = 0.012). Conclusion: Our results showed that the metabolic profile has a prognostic role not only for renal endpoints but also for CV endpoints in IgAN. BMI, hyperuricemia, hypertension, and diabetes have a predictive value for the prognosis of IgA nephropathy.

Preprint REVIEW | doi:10.20944/preprints202311.0461.v1

Ten Quick Tips for Accurate Reconstruction of Prokaryotic and Eukaryotic Genome-Scale Metabolic Models

Gabriela Canto-Encalada, Jenna Armstrong, Carlos Focil-Espinosa4, Ademikanra Adekunle-Fiyin, Ila Peeler, William R. Gebbie, Julio Nunez-Garcia, Alexis Saldivar, Diego Martinez, Cristal Zuniga

Subject: Biology And Life Sciences, Other Keywords: Genome-scale metabolic model reconstruction; manual curation; quick tips; systems biology

Online: 7 November 2023 (14:59:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0235.v1

Multiple Insecticide Resistance and Associated Metabolic-Based Mechanisms in a Myzus Persicae (Sulzer) Population Collected From Southeast China

Hu Jinfeng, Chen Feng, Wang Jun, Rao Wenhua, Lin Lei, Fan Guocheng

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Myzus persicae; insecticides; resistance monitoring; detoxification enzymes; protective enzymes; metabolic mechanism

Online: 2 August 2023 (13:46:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1132.v1

Benefits of Chronic Administration of a Carbohydrate-Free Diet on Biochemical and Morphometric Parameters in a Rat Model of Diet-Induced Metabolic Syndrome

Diana Alejandra Lares-Gutiérrez, Marisol Galván-Valencia, Irene Jazmín Flores-Baza, Blanca Patricia Lazalde-Ramos

Subject: Public Health And Healthcare, Other Keywords: carbohydrate-free diet; metabolic syndrome; biochemical parameters; morphometric parameters; rat model.

Online: 15 June 2023 (11:32:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1851.v1

Chemical Characterization, Antilipidemic Effect and Antiobesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome

Dulce Lourdes Morales Ferra, Miguel Ángel Zavala-Sánchez, Enrique Jiménez-Ferrer, Celeste Trejo-Moreno, Manasés González-Cortazar, Claudia Ivette Gamboa-Gómez, Fernando Guerrero-Romero, Alejandro Zamilpa

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Metabolic syndrome; hypercaloric diet; FFA; Ludwigia; corilagin; ellagic acid; gallic acid

Online: 26 May 2023 (04:40:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0882.v1

Thyroid Nodules and Obesity

Elpida Demetriou, Maria Fokou, Savvas Frangos, Panagiotis Papageorgis, Panayiotis A Economides, Aliki Ecocomides

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: thyroid nodules; obesity; inflammation; leptin; estrogen; cytokines; metabolic syndrome; car-cinogenesis

Online: 12 May 2023 (04:36:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0300.v1

Profiling of G-protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Saeed Al Mahri, Meshail Okla, Mamoon Rashid, Shuja Shafi Malik, Jahangir Iqbal, Maria Al Ibrahim, Ghida Dairi, Amer Mahmood, Manikandan Muthurangan, Ahmed Yaqinuddin, Sameer Mohammad

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: adipose tissue; adipogenesis; G-protein-coupled receptors; thermogenesis; obesity; metabolic syndrome

Online: 16 November 2022 (08:52:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202210.0230.v1

Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers

Olatunbosun Arowolo, J. Richard Pilsner, Oleg Sergeyev, Alexander Suvorov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PBDE; dose-response relationships; mTOR signaling; steroidogenesis; metabolic disruption; sperm epigenome

Online: 17 October 2022 (05:37:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0146.v1

Basal Metabolism, Body Composition and Physical Activity with Central Obesity in Adults: A Systematic Review

Génesis Chen, Claudia Lora, Diana Rodríguez, Victoria Valdés, Fabiana Pirán, Alex Brito, Israel Ríos-Castillo

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: central obesity; waist circumference; physical activity; basal metabolic rate; body composition

Online: 12 September 2022 (11:36:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0082.v1

Purinergic Receptors Are a Key Bottleneck in Tumor Metabolic Reprogramming: The Prime Suspect in Cancer Therapeutic Resistance

Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: therapy resistance; tumor microenvironment; metabolic reprogramming; purinergic receptor; cancer metabolism; immunometabolism

Online: 3 August 2022 (10:35:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0306.v1

Usefulness of Novel Atherogenic Lipid Indices for The Evaluation of Metabolic Status Leading to Coronary Heart Disease in A Real-World Survey of The Japanese Population

Isamu Matsunaga, Miyuki Ando, Yuki Tsubakimoto, Miyuki Nagasawa, Yoshimasa Kurumi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atherogenesis; metabolic status; lipid index; coronary heart disease; medical check-up

Online: 23 March 2022 (03:34:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0294.v1

Meal Timing, Meal Frequency and Metabolic Syndrome

Fatema Alkhulaifi, Charles Darkoh

Subject: Biology And Life Sciences, Virology Keywords: meal timing; meal frequency; skipping meals; fasting; obesity; metabolic syndrome; diabetes

Online: 22 March 2022 (04:20:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0382.v1

Employing Statistical Machine Reading for Inferring Key Concepts of a Research Field From a Body of Abstracts and Blog Posts

Wenfa Ng

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: statistical machine reading; metabolic engineering; concepts; terms and phrases; computational complexity

Online: 26 October 2021 (12:27:54 CEST)

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The world of science is drowned in a wealth of information. How to make sense of this wealth of published articles, blog posts and abstracts has become an important challenge given the importance of science to different aspects of societal function. At the crux of the issue lies the increasing trend where scientific discovery informs decision making at the societal level. One example, is the elucidation of the ozone hole to the promulgation of the Montreal Protocol in 1987, and documenting increasing atmospheric carbon dioxide concentration led to climate action and signing of the Paris Agreement in 2015. Hence, understanding a research field becomes an important need for many decision makers across different sectors of society. But, the scientific literature is cryptic and esoteric, and presents a significant barrier to comprehension. One approach to ameliorate the problem is statistical machine reading, which provides the critical capability of identifying key concepts that underpins a research field. Such important concepts help provide an incision point to gain further understanding of the field and initiating further conversation about the field. This work sought to validate the concept of whether applying statistical machine reading to a body of literature comprising short blog posts and abstracts of published articles help in understanding the field of metabolic engineering. One important angle pursued in this research is whether the tabulated list of terms and phrases identified by statistical machine reading could be creatively analyzed to gain a deeper understanding of the research field. For example, the most frequently occurring terms and phrases could describe key concepts of the research field. Moving down in frequency occurrence would be terms and phrases that describe methodologies and approaches of the field. Finally, less frequently occurring terms and phrases may be tools and resources used in the research field. Results validated the utility of statistical machine reading in identifying important terms and phrases associated with the research field. But the small dataset of blog posts and abstracts used in this study severely hampered the identification of most of the key concepts of metabolic engineering, which is a fairly broad field of research. Overall, statistical machine reading shows utility in identifying terms and phrases that could describe a field. However, the level of understanding is closely tied in to the breadth and depth of reading material available, which meant that the methodology is data intensive in nature. Future use of supercomputing or quantum computing could help alleviate constraints of computational capacity, and help tackle the exponential rise in computational complexity as the size of the reading material for machine reading expands.

Preprint ARTICLE | doi:10.20944/preprints202110.0035.v1

Distinguishing Between Isobaric Ions Using Microdroplet Hydrogen-Deuterium Exchange Mass Spectrometry

Xiaowei Song, Jia Li, Mohammad Mofidfar, Richard N. Zare

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: hydrogen-deuterium exchange; mass spectrometry; isobaric ions; ambient ionization; metabolic profiling

Online: 4 October 2021 (09:21:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0123.v1

Effects of Caffeinated and Decaffeinated Coffee Consumption on Metabolic Syndrome Parameters: A Systematic Review and Meta-Analysis of Data from Randomised Controlled Trials

Nur Nadiah Syuhada Ramli, Areej A Alkhaldy, Abbe Maleyki Mhd Jalil

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: metabolic syndrome; caffeinated coffee; decaffeinated coffee; green coffee extract; chlorogenic acid

Online: 4 August 2021 (22:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0434.v1

Going beyond Soil Conservation with the Use of Cover Crops in Mediterranean Sloping Olive Orchards

Luis F. Arias-Giraldo, Gema Guzmán Díaz, Miguel Montes-Borrego, David Gramaje, José A. Gómez, Blanca B. Landa

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: bacterial community composition; metabolic activity; microbial diversity; soil erosion; soil quality

Online: 16 June 2021 (10:23:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0342.v1

Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-analysis

Ifan Ali Wafa, Nando Reza Pratama, Nurizzah Farahiyah Sofia, Elsha Stephanie Anastasia, Tiffany Konstantin, Maharani Ayuputeri Wijaya, M. Rifqi Wiyono, Lilik Djuari, Hermina Novida

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 lockdown; diabetes mellitus; meta-analysis; metabolic control; systematic review

Online: 14 June 2021 (09:44:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0730.v1

The Role of Cellular Stress in Intrauterine Growth Restriction and Postnatal Dysmetabolism

Shelby L Oke, Daniel Barry Hardy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: intrauterine growth restriction (IUGR); metabolism; cell stress; cell death; metabolic syndrome

Online: 31 May 2021 (10:19:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0358.v1

Chimeric Drug Design with a Noncharged Carrier for Mitochondrial Delivery

Consuelo Ripoll, Pilar Herrero-Foncubierta, Virginia Puente-Muñoz, M. Carmen Gonzalez-Garcia, Delia Miguel, Sandra Resa, Jose M. Paredes, Maria J. Ruedas-Rama, Emilio Garcia-Fernandez, Miguel Martin, Mar Roldan, Susana Rocha, Herlinde De Keersmaecker, Johan Hofkens, Juan M. Cuerva, Angel Orte

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Antitumor agents; Fluorescence lifetime imaging; Medicinal chemistry; Metabolic drug; Mitochondrial carrier

Online: 15 December 2020 (08:35:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0301.v1

The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals

Natalie Wallis, Eleanor Raffan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Obesity; Genetics; Companion Animals; Metabolic Disease; Comparative Genomics; Dogs; Cats; Horses

Online: 14 October 2020 (10:51:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0245.v1

COVID-19 Comorbidity and Metabolic Syndrome: Is There a Molecular Basis?

Madhurima Basu, Chinmay Saha, Kamalika Roy Choudhury, Susmita Dutta, Sujoy Ghosh, Subhankar Chowdhury, Satinath Mukhopadhyay, Nitai P. Bhattacharyya

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: COVID-19; Metabolic syndrome; Comorbidity; Enrichment analysis; biological processes and pathways

Online: 21 June 2020 (09:52:10 CEST)

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Working Paper REVIEW

Corrective Metabolism: An Appreciation

Dan Fraenkel

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: metabolism; metabolic by products; overflow; damage; toxicity; repair; geneticist-induced stress

Online: 20 June 2019 (10:10:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0094.v1

Irreversibility as Thermodynamic Time

Charles C. Hwang

Subject: Physical Sciences, Thermodynamics Keywords: time; availability; irreversibility; time dilation; biological clock; metabolic efficiency; telomere; mitochondria

Online: 8 May 2019 (11:21:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0078.v1

Factors Influencing the Production of Different Types of Fatty Acid and Staphyloxanthin in the Staphylococcus aureus Membrane

Kiran Tiwari, Craig Gatto, Brian J. Wilkinson

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: membrane fatty acids composition; Staphylococcus aureus; staphyloxanthin; membrane fluidity; metabolic regulation

Online: 6 April 2018 (11:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1688.v1

Pharmacological Study of Amaranthus spinosus L. Root Extract on High-Fat Diet and Low-Dose Streptozocin-Induced Type 2 Diabetes Complications in Rats

Kokou Atchou, Povi Lawson-Evi, Kwashie Eklu-Gadegbeku

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Amaranthus spinosus; metabolic syndrome; type 2 diabetes; diabetes complications; retinopathy; renal fibrosis

Online: 24 October 2024 (10:01:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202410.1829.v1

Role of GLP-1 Agonists in Obesity: A Comprehensive Review

Kiran Sooraj Thirukonda Jegadeesh Babu, Ismail Arif Khan

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: GLP-1 receptor agonists; obesity; weight loss; liraglutide; semaglutide; pharmacotherapy; metabolic health

Online: 24 October 2024 (07:34:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0987.v1

Integrated Ultrasound Characterization of the Diet-Induced Obesity (Dio) Model in Young Adult C57bl/6j Mice: Assessment of Cardiovascular, Renal and Hepatic Changes

Sara Gargiulo, Virginia Barone, Denise Bonente, Tiziana Tamborrino, Giovanni Inzalaco, Lisa Gherardini, Eugenio Bertelli, Mario Chiariello

Subject: Medicine And Pharmacology, Other Keywords: obesity; metabolic syndrome; animal model; C57Bl/6J mouse; high frequency ultrasound imaging

Online: 12 July 2024 (04:09:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1458.v1

Hyperuricemia: Current State and Prospects

Wei-Zheng Zhang

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Hyperuricemia; microbiota; physical activity; caveolae; uric acid metabolism; cardiovascular disease; metabolic syndrome

Online: 20 June 2024 (15:10:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0498.v1

Assessment of Dietary and Lifestyle Quality Among the Romanian Population in the Post-Pandemic Period

Magdalena Mititelu, Violeta Popovici, Sorinel Marius Neacșu, Adina Magdalena Musuc, Stefan Sebastian Busnatu, Eliza Oprea, Steluța Boroghină, Andreea Mihai, Costin Teodor Streba, Dumitru Lupuliasa, Emma Gheorghe, Nadin Kebbewar, Carmen Elena Lupu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: healthy diet; balanced lifestyle; metabolic disorders; healthy habits; public health; nutritional education

Online: 8 April 2024 (07:07:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1614.v1

Optimizing Mesenchymal Stromal Cells Delivery: Present Status and New Frontiers in Regenerative Medicine

Jayeeta Giri

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Mesenchymal stromal cells; route of delivery; dose; Immunogenicity; Metabolic fitness; Potency assay

Online: 23 January 2024 (09:15:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0787.v1

Importance of Dyslipidaemia Treatment in Patients with Type 2 Diabetes Mellitus

Dominik Strikić, Andro Vujević, Dražen Perica, Dunja Leskovar, Kristina Paponja, Ivan Pećin, Iveta Merćep

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 diabetes mellitus; dyslipidaemia; metabolic disorder; pharmaceutical treatment; non-pharmaceutical treatment.

Online: 13 September 2023 (02:57:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0760.v1

Therapeutic Potential of the Kynurenine Pathway of Tryptophan Metabolism in Abdominal Migraine

Michal Fila, Cezary Chojnacki, Jan Chojnacki, Janusz Blasiak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: abdominal migraine; tryptophan metabolism; kynurenine; gut-brain axis; metabolic treatment in migraine

Online: 9 August 2023 (09:38:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1724.v1

Metabolic Alterations in Canine Mammary Tumors

Guilherme Henrique Tamarindo, Adriana Alonso Novais, Luiz Gustavo De Almeida Chuffa, Debora Aparecida Pires de Campos Zuccari

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: canine mammary tumors; metabolism, cancer; mitochondria; metabolic reprogramming; glucose; amino acids; lipids

Online: 25 June 2023 (08:00:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1450.v1

Oleocanthal Ameliorates Metabolic and Behavior Phenotypes in a Mouse Model of Alzheimer’s Disease

Euitaek Yang, Junwei Wang, Lauren N. Woodie, Michael W. Greene, Amal Kaddoumi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; blood-brain barrier; metabolic phenotype; sleep behavior; Promethion cages; oleocanthal

Online: 20 June 2023 (14:31:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1237.v1

Validation of Nutritrauma strategy for detection of harmful effects of medical nutritional treatment in critically ill patients in real life

Jordi Parisi, Itziar Martínez de Lagran, Mateu Serra-Prat, Maria Roca, Raquel Merino, Maria del Carmen De la Torre, Lluis Campins, Juan Carlos Yébenes

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Metabolic complications; critically ill; nutritrauma; medical nutrition therapy; enteral nutrition; parenteral nutrition.

Online: 16 June 2023 (12:10:10 CEST)

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Aims: Medical Nutritional Treatment (MNT) can be complex and associated to potential meta-bolic complications, which has been recently described as Nutritrauma. There is no data on the effect of applying this strategy in clinical practice. The aim of our work is to describe if applica-tion of Nutritrauma concept in real live is useful to detect metabolic complications associated to the prescription of MNT in critically ill patients. Methods: In this descriptive prospective study at a single center, we enrolled 30 consecutive crit-ical ill patients of a 14 beds medical – surgical Intensive Care Unit. The Nutritrauma strategy implementation was based in four M steps: Metabolic screening, MNT prescription, Biochemical Monitoring and Nutritional Management. The primary endpoint was to describe the metabolic complications of the MNT detected with Nutritrauma strategy. Secondary endpoint was to de-scribe the most frequent causes of inappropriate prescription. Results: We analysed 28 patients (mean age 69,7 ± 11,3 years; APACHE II 18,1 ± 8,1, SOFA 7,5 ± 3,7; Nutric Score modified 4,3 ± 2,01 and mean BMI 27,2 ± 3,8). The most frequent disease on admission was sepsis (46,4%). Length of ICU stay was 20,6 ± 15,1 days and 39,3% died during the ICU stay. Enteral nutrition (82,1%) was more frequent than parenteral nutrition (17,9%). During nutritional monitoring 54 specific analytical determinations were made. Hyperglycemia was the most frequent metabolic alteration (83,3% of the determinations). Electrolyte disturbance were hypocalcemia (50%), hypophosphatemia (29,6%) and hypokalemia (27,8%). The most frequent lipid profile abnormality were hypocholesterolemia (64,8%) and hypertriglyceridemia (27,8%). Furthermore, nutritional prescription was modified in the 53,6% of patients: increase protein dosage (25%), increase caloric dosage (21,4%) and change to an organ-specific diet (17,8%). Conclusions: The application of Nutritrauma strategy facilitate the detection of metabolic com-plications and the evaluation of the appropiate prescription of the MNT.

Preprint ARTICLE | doi:10.20944/preprints202305.1194.v1

Obesity-Associated with Prediabetes Increases the Risk of Breast Cancer Development and Progression- A Study on an Obese Rat Model with Impaired Glucose Tolerance

Prathap Reddy Kallamadi, Deepshika Esari, Utkarsh Reddy Addi, Rushendhiran Kesavan, Uday Kumar Putcha, Nagini Siddavaram, Geereddy Bhanuprakash Reddy

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Breast cancer; obesity; metabolic syndrome; rat model; DMBA; insulin signaling; PI3/Akt

Online: 17 May 2023 (05:25:25 CEST)

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It was found that patients with comorbidities of obesity and diabetes have a high risk of breast cancer occurrence and face worse breast cancer outcomes. Though several reports showed the reinforced link between obesity, diabetes, and prediabetes with breast cancer, the underlying molecular mechanism is still unknown. The present study aimed to investigate the underlying molecular link between increased risks of breast cancer due to coincident diabetes or obesity using a spontaneous obese rat model with impaired glucose tolerance (WNIN/GR-Ob rat). A single dose of solubilized DMBA suspension (40 mg/kg body weight) was orally administered to the animals at the age of 60 days to induce breast tumors. The tumor incidence, latency period, tumor frequency, and tumor volume were measured. Histology, immunohistochemistry, and immunoblotting were performed to evaluate the tumor morphology and expression levels of signal molecules. It was observed that the onset of breast tumor and latency period per tumor development were early in GR-Ob rats compared to respective lean rats. It was found that 62% of obese rats were bearing tumors, and in comparison, only 21% of the lean animals developed breast tumors. Overexpression of ER, PR, Ki67, and p53 markers was observed in tumor tissues of obese rats in comparison with lean rats. The levels of the hallmarks of cell proliferation and angiogenesis involved in IGF-1/PI3K/Akt/GSK3β/β-catenin signaling pathway molecules were upregulated in obese rat breast tumors compared to lean rats. Furthermore, obesity with prediabetes is associated with changes in IGF-1 signaling and acts on PI3K/Akt/GSK3β/β-catenin signaling, which results in quick cell proliferation and development of breast tumors in obese rats than the lean rats. These results indicate that the onset of the tumor and its development was faster in a spontaneous obese rat model with impaired glucose tolerance than their lean counterparts, with a higher percentage of tumor incidence.

Preprint ARTICLE | doi:10.20944/preprints202305.0837.v1

Metabolic Pathway Pairwise-Based Signature as a Potential Non-Invasive Diagnostic Marker in AD patients

Yunwen Feng, Xingyu Chen, Xiaohua Douglas Zhang, Chen Huang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Alzheimer's Disease; Noninvasive Diagnosis; Metabolic Abnormalities; Biomarker; Peripheral blood; Multi-Machine Learning

Online: 11 May 2023 (09:47:20 CEST)

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Alzheimer's disease (AD) is an incurable neurodegenerative disorder. Early screening, particularly in blood has been regarded as an effective approach for AD diagnosis and prevention. In addition, metabolic dysfunction has been demonstrated to be closely related to AD, which might be reflected in whole blood transcriptome. Hence, we hypothesized that establishment of diagnostic model based on metabolic signatures of blood is a workable strategy. To the end, we initially constructed metabolic pathway pairwise (MPP) signatures to characterize the interplay among metabolic pathways. Then, a series of bioinformatic methodologies, e.g., differential expression analysis, functional enrichment analysis, and network analysis, etc. were used to investigate the molecular mechanism behind AD. Moreover, an unsupervised clustering analysis based on the MPP signature profile via Non-Negative Matrix Factorization (NMF) algorithm was utilized to stratify AD patients. Finally, aimed at distinguishing AD patients from non-AD group, a metabolic pathway-pairwise scoring system (MPPSS) was established using multi-machine learning methods. As a result, many metabolic pathways correlated to AD were disclosed, including oxidative phosphorylation and fatty acid biosynthesis, etc. NMF clustering analysis divided AD patients into two subgroups (S1 and S2), which exhibit distinct activities of metabolism and immunity. Typically, oxidative phosphorylation in S2 exhibits a lower activity than that in S1 and non-AD group, suggesting the patients in S2 might possess a more compromised brain metabolism. Additionally, Immune infiltration analysis showed that the patients in S2 might have phenomena of immune suppression, compared with S1 and non-AD group. These findings indicated that S2 probably have a more severe progression of AD. Finally, MPPSS could achieve an AUC of 0.73 in training dataset, 0.71 in testing dataset and an AUC of 0.82 on weighted average in five external validation datasets. Overall, our study successfully established a novel metabolism-based scoring system for AD diagnosis using blood transcriptome, and provided new insight into the molecular mechanism of metabolic dysfunction implicated in AD.

Preprint TECHNICAL NOTE | doi:10.20944/preprints202305.0518.v1

Description and Validation of Flow-Through Chambers of Respirometry for Measuring Gas Exchange in Animal Trials

Rony Riveros, Rosiane de Souza Camargos, Raully Lucas Silva, Bruno Leme, Nilva Kazue Sakomura

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: farm anaimals,; farm animals; gas exchange; energy expenditure; metabolic rate; respirometric chambers

Online: 8 May 2023 (10:32:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0859.v1

Nutritional Aspects of Iron in Health and Disease

Edouard Charlebois, Kostas Pantopoulos

Subject: Medicine And Pharmacology, Other Keywords: Iron deficiency; iron overload; anemia; heme; metabolic syndrome; cardiovascular disease; cancer; microbiome

Online: 24 April 2023 (12:48:31 CEST)

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