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Preprint ARTICLE | doi:10.20944/preprints202401.0202.v1

Integrating High-Resolution Mass Spectral Data, Bioassays and Computational Models to Annotate Bioactives in Botanical Extracts: Case Study – Analysis of Centella asiatica Extract Associates Di-Caffeoylquinic Acids with Protection against Amyloid-β Toxicity in an MC65 cell model

Armando Alcazar-Magana, Ashish Vaswani, Kevin S. Brown, Yuan Jiang, Md Nure Alam, Maya Caruso, Parnian Lak, Paul Cheong, Nora E. Gray, Joseph F. Quinn, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier

Subject: Biology And Life Sciences, Life Sciences Keywords: Centella asiatica; bioactives; bioassays; computational methods; Elastic Net; spectral networks; GNPS

Online: 3 January 2024 (09:30:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0357.v1

Predictive Modeling of Alzheimer's and Parkinson's Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid

Nathan Hwangbo, Xinyu Zhang, Daniel Raftery, Haiwei Gu, Shu-Ching Hu, Thomas J. Montine, Joseph F. Quinn, Kathryn A. Chung, Amie L. Hiller, Dongfang Wang, Qiang Fei, Lisa Bettcher, Cyrus Zabetian, Elaine R. Peskind, Ge Li, Daniel Promislow, Marie Y. Davis, Alexander Franks

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: predictive modeling; biomarker; cerebrospinal fluid; cross-sectional study; neurodegenerative disease

Online: 24 January 2022 (12:59:55 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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