Damaged and defective fiber-reinforced polymer composites were inspected by magnetic resonance imaging. Nondestructive examination was conducted with samples immersed in saline water solution simulating biofluids permanently in contact with load-bearing orthopedic implants. Size, geometry, orientation and positioning of translaminar and delamination fractures in the test pieces were characterized. In this regard, translaminar damages required all primary imaging planes, namely, axial, coronal and sagittal to be fully portrayed, whereas only sagittal slicing was demanded for entire depiction of delaminations. Size and spatial distribution of water clusters formed in composite samples, as well as surface finishing features of the specimens were also outlined. The evaluated imaging technique has shown high potential for nondestructive inspection of fiber-reinforced polymer parts operating in liquid proton-rich media.

Cancer is a multifactorial disease that continues to increase. Lignans are known to be important anticancer agents. However, due to the structural diversity of lignans, it is difficult to associate anticancer activity with a particular subclass. Therefore, the present study sought to evaluate the association of lignan subclasses with antitumor activity, considering the genetic profile of the variants of the selected targets. For this, predictive models were built against the targets tyrosine-protein kinase ABL (ABL), epider-mal growth factor receptor erbB1 (EGFR), histone deacetylase (HDAC), Serine/threonine-protein kinase mTOR (mTOR) and Poly [ADP-ribose] polymerase-1 (PARP1). Then, mapped single nucleotide polymorphisms and designed target mutations, and performed molecular docking with the lignans with the best predicted biological activity. The results showed more anticancer activity in the dibenzocyclooctadiene, furofuran and aryltetralin subclasses. The lignans with the best predictive values of biological activity showed varying binding energy results in the presence of certain genetic variants.